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General Information
Symbol
Dmel\ptc5
Species
D. melanogaster
Name
FlyBase ID
FBal0028495
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ptc7M59, ptc7M
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

83% of ptchdl/ptc5 transheterozygotes show head capsule defects.

Mutant embryos show a 2-3 fold increase in the number of Bolwig's organ neurons compared to wild type.

Most clones in the retina induce ectopic furrows. The axons of photoreceptor cells of ectopic ommatidia from these furrows do not always follow the normal polarity field towards the posterior and the optic stalk.

Clones induced in the eye disc cause circular ectopic furrows. Rotation of the ommatidia generated by circular furrows is as predicted by the two vector model of ommatidial rotation, provided that the equator pre-exists the furrow and is not altered by perturbations induced by ptc clones.

Clones of mutant wing tissue induce growth of anterior tissue, as mirror image duplications of anterior wing. Duplicated tissue includes no veins but is flanked by ectopic vein 3. At the wing margin, ptc mutant clones do not produce chemosensory bristles. No abnormal posterior compartment structures are observed in ptc clones.

homozygous lethal

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

ptc5 is an enhancer of wing | anterior | proximal phenotype of hhh9D

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Enhances the rough eye phenotype caused by expression of atoScer\UAS.cJa under the control of Scer\GAL4sca-109-68.

Clones of ptc5 Df(2R)enE double mutant wing tissue induce growth of anterior tissue, as mirror image duplications of anterior wing. No abnormal posterior compartment structures are observed in ptc clones, though mutant pattern outgrowths occur in ptc, Df(2R)enE double mutant patches.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (10)