FlyBase Allele Report: Dmel\ptc[5]

General Information

Symbol

Dmel\ptc⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0028495

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

Also Known As

ptc^7M59, ptc^7M

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hidalgo and Ingham, 1990, Phillips et al., 1990, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Phillips et al., 1990)

some die during embryonic stage

(Phillips et al., 1990)

Phenotype Manifest In

adult head capsule (with ptc^hdl)

(Shyamala and Bhat, 2002)

Bolwig organ

(Suzuki and Saigo, 2000)

eye disc

(Reifegerste et al., 1997, Ma and Moses, 1995)

eye disc & morphogenetic furrow

(Ma and Moses, 1995)

eye disc morphogenetic furrow | ectopic

(Reifegerste et al., 1997, Ma and Moses, 1995)

ommatidium

(Ma and Moses, 1995)

photoreceptor cell & axon

(Reifegerste et al., 1997)

wing

(Tabata et al., 1995)

wing vein

(Tabata et al., 1995)

wing vein L3 | ectopic

(Tabata et al., 1995)

Detailed Description

Statement

Reference

83% of ptc^hdl/ptc⁵ transheterozygotes show head capsule defects.

(Shyamala and Bhat, 2002)

Mutant embryos show a 2-3 fold increase in the number of Bolwig's organ neurons compared to wild type.

(Suzuki and Saigo, 2000)

Most clones in the retina induce ectopic furrows. The axons of photoreceptor cells of ectopic ommatidia from these furrows do not always follow the normal polarity field towards the posterior and the optic stalk.

(Reifegerste et al., 1997)

Clones induced in the eye disc cause circular ectopic furrows. Rotation of the ommatidia generated by circular furrows is as predicted by the two vector model of ommatidial rotation, provided that the equator pre-exists the furrow and is not altered by perturbations induced by ptc clones.

(Ma and Moses, 1995)

Clones of mutant wing tissue induce growth of anterior tissue, as mirror image duplications of anterior wing. Duplicated tissue includes no veins but is flanked by ectopic vein 3. At the wing margin, ptc mutant clones do not produce chemosensory bristles. No abnormal posterior compartment structures are observed in ptc clones.

(Tabata et al., 1995)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ptc⁵ is an enhancer of visible phenotype of Scer\GAL4^sca-109-68, ato^UAS.cJa

(White and Jarman, 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

ptc⁵ is an enhancer of eye phenotype of Scer\GAL4^sca-109-68, ato^UAS.cJa

(White and Jarman, 2000)

ptc⁵ is an enhancer of ommatidium phenotype of Scer\GAL4^sca-109-68, ato^UAS.cJa

(White and Jarman, 2000)

ptc⁵ is an enhancer of wing | anterior | proximal phenotype of hh^h9D

(Kojima et al., 1994)

Other

Statement

Reference

Df(2R)en^E, ptc⁵ has wing phenotype

(Tabata et al., 1995)

Df(2R)en^E, ptc⁵ has wing vein phenotype

(Tabata et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68.

(White and Jarman, 2000)

Clones of ptc⁵ Df(2R)en^E double mutant wing tissue induce growth of anterior tissue, as mirror image duplications of anterior wing. No abnormal posterior compartment structures are observed in ptc clones, though mutant pattern outgrowths occur in ptc, Df(2R)en^E double mutant patches.

(Tabata et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ptc⁵

ptc^7M59

(Shyamala and Bhat, 2002, Suzuki and Saigo, 2000, Reifegerste et al., 1997, Kojima et al., 1994, Hidalgo and Ingham, 1990)

ptc^7M

(Ma and Moses, 1995, Tabata et al., 1995, Phillips et al., 1990, Tearle and Nusslein-Volhard, 1987)

tuf⁵

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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