FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RhoLN25.hs
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General Information
Symbol
Dmel\RhoLN25.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0061654
Feature type
allele
Associated gene
Dmel\RhoL
Associated Insertion(s)
Carried in Construct
P{hs-RhoL.N25}
Key Links
Transgenic product class
missense_variant
(Murphy and Montell, 1996)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Murphy and Montell, 1996)
Mutagen
in vitro construct
(Murphy and Montell, 1996)
Progenitor genotype
Carried in construct
P{hs-RhoL.N25}
Cytology
Description

Expression of a mutated form of RhoL (carries the amino acid replacement T25N) is driven by an Hsp70 promoter.

(Murphy and Montell, 1996)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
RhoL
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heat induced expression in ovaries causes nurse cells to collapse and fuse together concomitantly with subcortical actin breakdown. The actin cage that normally surrounds stage 11 nurse cell nuclei is absent resulting in ring canals becoming obstructed by the nuclei and failure to complete cytoplasm transfer.

      (Murphy and Montell, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Generates a dominant negative protein.

      (Murphy and Montell, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RhoLN25.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)