FB2026_03 , released September 17, 2026
Allele: Dmel\pbRev23.HSPB
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General Information
Symbol
Dmel\pbRev23.HSPB
Species
D. melanogaster
Name
FlyBase ID
FBal0062509
Feature type
allele
Associated gene
Dmel\pb
Associated Insertion(s)
Carried in Construct
P{HSPBRev23}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Benassayag et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Benassayag et al., 1997)
Mutagen
ethyl methanesulfonate
(Benassayag et al., 1997)
Progenitor genotype
Carried in construct
P{HSPBRev23}
Cytology
Description

An Hsp70 promoter governing expression of pb minigene that includes all the pb coding region apart from the 15bp alternatively spliced microexon. Contains a C224G amino acid replacement within the pb coding sequence.

(Benassayag et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
pb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,711,846..6,711,846 [-]
Nucleotide change:

T6711846G

Reported nucleotide change:

T123G

Amino acid change:

C224G | pb-PA; C219G | pb-PB; C219G | pb-PC; C214G | pb-PD

Reported amino acid change:

C224G

(Benassayag et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying one or two copies of pbRev23.HSPB are wild type. Flies carrying pbRev23.HSPB are more active and agile than flies carrying the progenitor allele pbhs.PB.

      (Benassayag et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      pbRev23.HSPB fails to rescue pb4

      (Benassayag et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HSPBRev23
      (Benassayag et al., 1997)
      pbRev23.HSPB
      Name Synonyms
      Secondary FlyBase IDs
        References (1)