FB2026_02 , released June 18, 2026
Allele: Dmel\kuzDN.DMR
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General Information
Symbol
Dmel\kuzDN.DMR
Species
D. melanogaster
Name
FlyBase ID
FBal0062776
Feature type
allele
Associated gene
Dmel\kuz
Associated Insertion(s)
Carried in Construct
P{kuz-DMR.DN}
Key Links
Transgenic product class
dominant_negative_variant
(Pan and Rubin, 1997)
inframe_deletion
(Pan and Rubin, 1997)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Pan and Rubin, 1997)
inframe_deletion
(Pan and Rubin, 1997)
Mutagen
in vitro construct
(Pan and Rubin, 1997)
Progenitor genotype
kuz1.DMR
(Pan and Rubin, 1997)
Carried in construct
P{kuz-DMR.DN}
Cytology
Description

A 4.3kb dpp disc-specific enhancer followed by the Hsp70 basal promoter drive expression of a dominant-negative form of kuz. The Pro-domain and metalloprotease domain are deleted, leaving the SP, disintegrin domain, Cys-rich domain, transmembrane domain and intracellular domain intact.

(Pan and Rubin, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
dpp
Encoded product / tool
kuz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Supernumerary bristles on the notum and notches on the wing blade.

      (Pan and Rubin, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      kuzDN.DMR has scutum & macrochaeta phenotype, enhanceable by NS-317

      (Pan and Rubin, 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Protein functions in a dominant negative manner.

      (Pan and Rubin, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      kuzDN.DMR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)