FlyBase Allele Report: Dmel\chb[v40]

(Maiato et al., 2002, Lemos et al., 2000, Fedorova et al., 1997, Fedorova et al., 1997, Omel'yanchuk et al., 1997, Omelyanchuk and Lebedeva, 1997, Trunova et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle

(Lemos et al., 2000, Omel'yanchuk et al., 1997, Omelyanchuk and Lebedeva, 1997)

lethal - all die during embryonic stage (with Df(3L)31A)

(Lemos et al., 2000)

lethal - all die during embryonic stage | recessive

(Lemos et al., 2000)

some die during embryonic stage (with Df(3L)31A)

(Lemos et al., 2000)

some die during embryonic stage | recessive

(Lemos et al., 2000)

Phenotype Manifest In

centriole

(Fedorova et al., 1997)

ganglion & mitotic cell cycle & larva

(Fedorova et al., 1997)

larval brain & nuclear chromosome

(Fedorova et al., 1997, Omelyanchuk and Lebedeva, 1997)

mitotic cell cycle

(Lemos et al., 2000)

mitotic cell cycle & neuroblast

(Fedorova et al., 1997)

spindle

(Fedorova et al., 1997)

testis

(Inoue et al., 2004)

Detailed Description

Statement

Reference

chb^v40 testes are aberrant and diminutive.

(Inoue et al., 2004)

Third instar larval brains exhibit polyploidy and circular mitotic figures and are generally arrested in metaphase or prometaphase. Most cells show highly condensed chromatin and polyploid cells, cells with circular mitotic figures and other abnormal anaphases are seen.

(Lemos et al., 2000)

Almost all metaphases have an even number of chromosomes. Circular mitotic figures and monopolar anaphases are evident. Mutant chromosomes fail to separate at prometaphase.

(Fedorova et al., 1997)

The ganglia of homozygous larvae contain highly polyploid cells. Unipolar chromosome spindles are seen. Circular mitotic figures (circles of chromosomes with centromeres pointing inwards and chromatid arms pointing outwards) are seen in homozygous neuroblasts.

(Fedorova et al., 1997)

Ganglia of homozygotes exhibit highly condensed chromosomes, chromosomes appear as bows: centriole disjunction is blocked. Mutation affects both somatic and germ cells.

(Fedorova et al., 1997)

Anomalous mitoses in homozygous larvae.

(Omel'yanchuk et al., 1997)

Abnormal mitotic activity as assayed in the larval brain. High degree of polyploidy. Chromosome non-disjunction.

(Omelyanchuk and Lebedeva, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

The effects on viability, mitotic phenotype and mitotic progression suggest an allelic series: chb^EP3515 < chb^v40 < chb^EP3403 < chb^P4.

(Lemos et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

chb(v40)

(Fedorova et al., 1997)

chb¹

chb^v40

mast¹

(Maiato et al., 2002)

mast^P1

(Lemos et al., 2000)

orbit¹

(Inoue et al., 2004)

v40¹

(Omel'yanchuk et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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