FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CCT5k06005
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General Information
Symbol
Dmel\CCT5k06005
Species
D. melanogaster
Name
FlyBase ID
FBal0064701
Feature type
allele
Associated gene
Dmel\CCT5
Associated Insertion(s)
P{lacW}CCT5k06005
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}CCT5k06005
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intrinsic cardiomyopathy
      CEA
      (Melkani et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CCT5k06005 homozygotes exhibit cardiac dysfunction under either Light:Light or Light:Dark cycles, as shown by significant increases in heart period, arrhythmia, and diastolic and systolic intervals, and by small decreases in fractional shortening, and diastolic and systolic diameter, as compared to controls.

      (Melkani et al., 2017)

      In contrast to wild type, Cct5k06005 mutant flies subjected to 12-hour daytime-restricted feeding (TRF) do not exhibit improved cardiac contractility relative to genotype and age-matched ad libitum feeding (ALF) flies, as measured by heart period and arrhythmicity.

      (Gill et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      CCT5k06005 is an enhancer of visible | male phenotype of Pc11

      (Shaheen et al., 2021)

      CCT5k06005 is an enhancer of visible | male phenotype of Pc1

      (Shaheen et al., 2021)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      CCT5k06005 is an enhancer of sex comb phenotype of Pc11

      (Shaheen et al., 2021)

      CCT5k06005 is an enhancer of sex comb phenotype of Pc1

      (Shaheen et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Complements: SmD302833. Complements: Cam03909. Complements: SmD3k13101.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CCT5K06005
      (Shaheen et al., 2021)
      CCT5k06005
      Cct5k06005
      l(2)06444k06005
      (BDGP Project Members, 1994-1999)
      l(2)k06005
      (Spradling et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)