FlyBase Allele Report: Dmel\da[KE383]

General Information

Symbol

Dmel\da^KE383

Species

D. melanogaster

Name

FlyBase ID

FBal0064917

Feature type

allele

Associated gene

Dmel\da

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wulbeck et al., 1994)

Mutagen

Progenitor genotype

Cytology

Description

Point mutation.

(Wulbeck et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Wulbeck et al., 1994)

some die during embryonic stage | recessive

(Wulbeck et al., 1994)

Phenotype Manifest In

presumptive embryonic/larval central nervous system

(Wulbeck et al., 1994)

presumptive embryonic/larval peripheral nervous system

(Wulbeck et al., 1994)

Detailed Description

Statement

Reference

Homozygous embryos have mild CNS and PNS defects.

(Wulbeck et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

da^IIP106/da^KE383 has lethal | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106/da^KE383 has lethal | embryonic stage phenotype, suppressible | partially by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^KE383 has lethal | recessive | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^KE383 has lethal | recessive | embryonic stage phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

Phenotype Manifest In

Suppressed by

Statement

Reference

da^IIP106/da^KE383 has phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^IIP106/da^KE383 has phenotype, suppressible | partially by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^KE383 has central nervous system | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^KE383 has central nervous system | embryonic stage phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

da^KE383 has peripheral nervous system | embryonic stage phenotype, suppressible by da::Drer\tcf3a^HLH

(Wulbeck et al., 1994)

da^KE383 has peripheral nervous system | embryonic stage phenotype, suppressible by da::Drer\tcf3a^bHLH

(Wulbeck et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Embryonic phenotype can be rescued by constructs carrying da::Brer\E12^HLH or da::Brer\E12^bHLH but no flies emerge. Embryonic lethality is rescued but flies die as larvae. da^IIP106/da^KE383 transheterozygotes carrying da::Brer\E12^HLH survive to adulthood. Flies exhibit defects in wings and sensory organs. da::Brer\E12^bHLH does not allow rescue to adulthood.

(Wulbeck et al., 1994)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

da^KE383

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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