FB2026_02 , released June 18, 2026
Allele: Dmel\wupAD3
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General Information
Symbol
Dmel\wupAD3
Species
D. melanogaster
Name
FlyBase ID
FBal0065583
Feature type
allele
Associated gene
Dmel\wupA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Prado et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: L188F. L188 immediately precedes the actin-binding domain.

(Prado et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:18,106,922..18,106,922 [-]
Nucleotide change:

C18106922T

Amino acid change:

L127F | wupA-PA; L127F | wupA-PB; L127F | wupA-PC; L127F | wupA-PD; L127F | wupA-PE; L127F | wupA-PF; L188F | wupA-PG; L188F | wupA-PH; L127F | wupA-PI; L127F | wupA-PJ; L103F | wupA-PK; L103F | wupA-PL; L103F | wupA-PM

Reported amino acid change:

L188F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Prado et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      embryonic somatic muscle & Z disc (with wupAhdp-2)

      (Marin et al., 2004)

      indirect flight muscle & Z disc (with wupAhdp-2)

      (Marin et al., 2004)
      Detailed Description
      Statement
      Reference

      wupAhdp-2/wupAD3 embryos have only subtle abnormalities in the somatic muscles, such as disordered alignment of Z discs and failure to anchor all thin filaments from a sarcomere. The indirect flight muscles of wupAhdp-2/wupAD3 adults show abnormalities in the central part of some Z discs.

      (Marin et al., 2004)

      Males and females of wupAhdp-2/wupAD3 genotype show a normal wing position in 95% cases, the remaining 5% still show a variety of abnormal wing positions. The IFM and TDT muscles are restored to a great extent. Sarcomere structure is also restored thought they are about 25% longer than wild type. Flight performance and jump ability demonstrate a functional recovery of the muscles. IFM defects of wupAhdp-3 cannot be suppressed.

      (Prado et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      wupAD3
      Name Synonyms
      Secondary FlyBase IDs
        References (3)