FB2026_02 , released June 18, 2026
Allele: Dmel\shiVS2
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General Information
Symbol
Dmel\shiVS2
Species
D. melanogaster
Name
FlyBase ID
FBal0065687
Feature type
allele
Associated gene
Dmel\shi
Associated Insertion(s)
Carried in Construct
Also Known As
Sushi
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ramaswami et al., 1993)
Progenitor genotype
shi2
(Narayanan et al., 2005)
Cytology
Description

Amino acid replacement: R59C.

(Narayanan et al., 2005)

The R59C substitution maps near the switch 1 region of the GTPase domain of the shi protein.

(Narayanan et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:15,894,706..15,894,706 [+]
Nucleotide change:

C15894706T

Amino acid change:

R54C | shi-PA; R54C | shi-PB; R54C | shi-PC; R54C | shi-PE; R54C | shi-PF; R54C | shi-PG; R54C | shi-PH; R54C | shi-PI; R54C | shi-PJ; R54C | shi-PK; R54C | shi-PL; R54C | shi-PM; R54C | shi-PN; R54C | shi-PO; R54C | shi-PP

Reported amino acid change:

R59C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Narayanan et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies are not paralytic at 28oC. Mutation also suppresses the paralytic phenotype of shi1, the eye, thoracic bristle, wing and wing margin bristle phenotypes.

      (Ramaswami et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Revertant: complete

      (Narayanan et al., 2005)

      The R59C substitution acts as a intragenic suppressor of the paralytic phenotype and synaptic defects of shi2.

      (Narayanan et al., 2005)

      Selected as: suppressor of shi2.

      (Narayanan et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Sushi
      (Narayanan et al., 2005, Ramaswami et al., 1993)
      VS2
      (Narayanan et al., 2005)
      shiVS2
      (Narayanan et al., 2005)
      shivs2
      (Narayanan et al., 2005)
      Name Synonyms
      Suppressor of shi
      (Narayanan et al., 2005)
      Secondary FlyBase IDs
        References (2)