FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tgo3
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General Information
Symbol
Dmel\tgo3
Species
D. melanogaster
Name
FlyBase ID
FBal0082186
Feature type
allele
Associated gene
Dmel\tgo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sonnenfeld et al., 1997)
Progenitor genotype
Cytology
Description

Amino acid replacement: W578term.

(Sonnenfeld et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,017,950..9,017,950 [-]
Nucleotide change:

G9017950A

Amino acid change:

W578term | tgo-PA; W578term | tgo-PB

Reported amino acid change:

W578term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Sonnenfeld et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In tgo3 homozygous embryos branching of the terminal cells is absent and no connections develop between each side of the tracheal dorsal trunk so the dorsal trunk does not form a continuous tubular structure. In addition, the transverse connectives misroute resulting in an absence of dorsal branches. There is also an absence of ganglionic branches in the ventral nerve cord in tgo3 homozygous embryos.

      (Sonnenfeld et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominant enhancer of the Df(3R)ss-D114.4/+ weak antenna to tarsus transformation phenotype.

      (Emmons et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tgo3
      (Thanawala et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)