FlyBase Allele Report: Dmel\tgo[5]

General Information

Symbol

Dmel\tgo⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0098639

Feature type

allele

Associated gene

Dmel\tgo

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele

Mutagen

Nature of the Allele

Allele class

hypomorphic allele

(Tajiri et al., 2007)

Mutagen

Progenitor genotype

Cytology

Description

Nucleotide substitution: C1737T.

(Tajiri et al., 2007)

Amino acid replacement: Q468term.

(Tajiri et al., 2007)

Nucleotide substitution: A3049G.

(Tajiri et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,018,281..9,018,281 [-]

Nucleotide change:

C9018281T

Reported nucleotide change:

C?T

Amino acid change:

Q468term | tgo-PA; Q468term | tgo-PB

Reported amino acid change:

Q468term

(Tajiri et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive | somatic clone

(Emmons et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

tgo⁵ clones (generated using the MARCM technique) of the ddaD and ddaC neurons do not show any obvious dendritic defects.

(Kim et al., 2006)

Mutant embryos have tracheal defects.

(Lavista-Llanos et al., 2002)

Close to a null allele. Homozygous clones have no effect in the proximal antennal segments (segments 1 and 2). Clones transform the distal part of antennal segment 3, the basal cylinder and arista to a tarsus that is deleted for most of its segments. Arista-claw intermediates are often present, and the identity of the proximal part of antennal segment 3 is unaffected. Homozygous clones in the distal part of the leg often show pattern deletions that include the second through fourth tarsal segments. Clones in the proximal part of the leg have no effect. Homozygous clones in the maxillary palps result in distal deletions. Homozygous clones in the wing hinge region cause the wing to be held out away from the body. Homozygous clones show a strong reduction in bristle size. Homozygous clones in the proboscis, vibrissae, dorsal head, dorsal thorax, wings and abdomen appear normal, with the exception of a reduction in bristle size.

(Emmons et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

tgo[+]/tgo⁵ is a suppressor of female germline stem cell phenotype of piwi²

(Smulders-Srinivasan and Lin, 2003)

Other

Statement

Reference

Df(3R)ss-D114.4/+, tgo⁵ has arista phenotype

(Emmons et al., 1999)

Df(3R)ss-D114.4/+, tgo⁵ has basal cylinder phenotype

(Emmons et al., 1999)

Df(3R)ss-D114.4/+, tgo⁵ has third segment of antenna phenotype

(Emmons et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Dominant enhancer of the Df(3R)ss-D114.4/+ weak antenna to tarsus transformation phenotype. The antennae from Df(3R)ss-D114.4/tgo⁵ heterozygotes have a swelling at the base of the arista and bracted bristles on the basal cylinder and the distal part of antennal segment 3.

(Emmons et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tgo⁶

(Emmons et al., 1999)

tgo⁷

(Emmons et al., 1999)

tgo¹

(Emmons et al., 1999)