FB2026_03 , released September 17, 2026
Allele: Dmel\rdgBT59E.ninaE
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General Information
Symbol
Dmel\rdgBT59E.ninaE
Species
D. melanogaster
Name
FlyBase ID
FBal0082297
Feature type
allele
Associated gene
Dmel\rdgB
Associated Insertion(s)
Carried in Construct
P{rdgB-T59E}
Key Links
Transgenic product class
missense_variant
(Milligan et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Milligan et al., 1997)
Mutagen
in vitro construct
(Milligan et al., 1997)
Progenitor genotype
Carried in construct
P{rdgB-T59E}
Cytology
Description

Full length mutant rdgB (carries the amino acid replacement T59E) is expressed under the control of the ninaE promoter.

(Milligan et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
rdgB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing rdgBT59E.ninaE in a wild-type background have a dominant retinal degeneration phenotype. The flies show a light-enhanced and dose-dependent loss of the deep pseudopupil. Flies have a reduction in the size of the R1-R6 outer rhabdomeres, and have a few holes in the retina. The electroretinogram light response amplitude of flies expressing rdgBT59E.ninaE in a wild-type background is reduced by approximately 40% compared to wild-type.

      (Milligan et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      rdgBT59E.ninaE partially rescues rdgB2

      (Milligan et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rdgBT59E.ninaE
      Name Synonyms
      Secondary FlyBase IDs
        References (1)