FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CalrS114307
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General Information
Symbol
Dmel\CalrS114307
Species
D. melanogaster
Name
FlyBase ID
FBal0082323
Feature type
allele
Associated gene
Dmel\Calr
Associated Insertion(s)
P{lacW}CalrS114307
Carried in Construct
Also Known As
l(3)S114307
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Salzberg et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{lacW}CalrS114307
Cytology
Description

P{lacW} insertion in the 5' UTR, 28bp upstream of the Crc AUG codon.

(Prokopenko et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF175911
AF175912
AF175913
AF175914
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos exhibit variable loss of neurons, decreased staining with 22C10 especially in the CNS and disorganization of the PNS, pathfinding defects and subtle morphological defects.

      (Salzberg et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

      (Salzberg et al., 1997)
      External Crossreferences and Linkouts ( 4 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      1143/7
      (Salzberg et al., 1997)
      CalrS114307
      (Chen and Sun, 2025)
      CrcS114307
      (Kuraishi et al., 2009)
      l(3)S114307
      (Prokopenko et al., 2000, Bloomington Drosophila Stock Center, 1998.6.3)
      l(3)s114307
      (Gamo et al., 2003)
      potpS114307
      Name Synonyms
      Secondary FlyBase IDs
        References (7)