FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\norpAC1094S.hs
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General Information
Symbol
Dmel\norpAC1094S.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0082387
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
norpAC1094S
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Expression of a mutated form of norpA (carries the C1094Samino acid replacement) is driven by an Hsp70 promoter.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The amplitude of quantum bumps in photoreceptors is smaller in animals expressing norpAC1094S.hs in a norpA36 background than in wild type (when ATP is present in the intracellular solution during recordings).

Patch-clamp whole cell recordings show termination of light-induced currents that is four orders of magnitude slower than wild type in flies carrying norpAC1094S.hs in a norpA36 background.

Expression is wild type background leads to wild type physiology of ERG recordings. Mutants exhibit long latencies and reduced initial slopes: activation of the visual response is delayed. Following termination of light repolarisation is prolonged. The deactivation waveform of norpAC1094S.hs inaC2 double mutants is similarly delayed as in norpAC1094S.hs but requires more time to completely repolarise and the latency to activation is almost identical to that of norpAC1094S.hs. norpAC1094S.hs inaC2 double mutants display a much reduced response to light. norpAC1094S.hs inaD1 double mutants display a profound loss of the visual response.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
norpAC1094S.hs
Name Synonyms
Secondary FlyBase IDs
    References (3)