The amplitude of quantum bumps in photoreceptors is smaller in animals expressing norpAC1094S.hs in a norpA36 background than in wild type (when ATP is present in the intracellular solution during recordings).
Patch-clamp whole cell recordings show termination of light-induced currents that is four orders of magnitude slower than wild type in flies carrying norpAC1094S.hs in a norpA36 background.
Expression is wild type background leads to wild type physiology of ERG recordings. Mutants exhibit long latencies and reduced initial slopes: activation of the visual response is delayed. Following termination of light repolarisation is prolonged. The deactivation waveform of norpAC1094S.hs inaC2 double mutants is similarly delayed as in norpAC1094S.hs but requires more time to completely repolarise and the latency to activation is almost identical to that of norpAC1094S.hs. norpAC1094S.hs inaC2 double mutants display a much reduced response to light. norpAC1094S.hs inaD1 double mutants display a profound loss of the visual response.