FlyBase Allele Report: Dmel\aay[S042314]

(Andrade and Cook, 2005.7.22, Andrade and Cook, 2003.6.2, Prokopenko et al., 2000, Szeged Stock Center, 1998-, Deak et al., 1997, Salzberg et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Kong et al., 2010)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant | conditional

(Kong et al., 2010)

increased rate of movement | conditional

(Kong et al., 2010)

lethal | recessive

(Szeged Stock Center, 1998-)

lethal - all die before end of P-stage | recessive

(Deak et al., 1997, Salzberg et al., 1997)

some die during pharate adult stage | recessive

(Deak et al., 1997, Salzberg et al., 1997)

Phenotype Manifest In

larval intersegmental nerve | embryonic stage

(Salzberg et al., 1997)

Detailed Description

Statement

Reference

aay^S042314 flies exhibit increased ethanol-induced hyperactivity and reduced ethanol sedation sensitivity and sedation tolerance compared to controls.

(Kong et al., 2010)

Embryos exhibit axonal misrouting, the ISN crosses segment boundaries.

(Salzberg et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4548

y¹ w^67c23; P{lacW}aay^S042314/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Comments

Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

(Salzberg et al., 1997)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

0423/14

(Deak et al., 1997)

423/14

(Salzberg et al., 1997)

S042314

(Kong et al., 2010)

aay^S042314

l(3)S042314

(Prokopenko et al., 2000, Bloomington Drosophila Stock Center, 1998.6.3)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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