FlyBase Allele Report: Dmel\EcR[E261st]

General Information

Symbol

Dmel\EcR^E261st

Species

D. melanogaster

Name

FlyBase ID

FBal0083493

Feature type

allele

Associated gene

Dmel\EcR

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bender et al., 1997)

Progenitor genotype

Cytology

Description

Mutation falls just upstream of the DNA-binding domain (numbering with respect to the EcR-B1 open reading frame).

(Bender et al., 1997)

Nucleotide substitution: G?T.

(Bender et al., 1997)

Amino acid replacement: E261term.

(Bender et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:6,094,970..6,094,970 [-]

Nucleotide change:

G6094970T

Reported nucleotide change:

G?T

Amino acid change:

Reported amino acid change:

E261term

(Bender et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Tsai et al., 1999)

lethal - all die during embryonic stage | recessive

(Bender et al., 1997)

some die during embryonic stage | recessive

(Bender et al., 1997)

Phenotype Manifest In

abdominal tergite

(Tsai et al., 1999)

wing

(Tsai et al., 1999)

Detailed Description

Statement

Reference

EcR^A483T/EcR^E261st shows greater than 95% lethality. Adult escapers show significant delays in development, blistered wings and defective tergites.

(Tsai et al., 1999)

EcR^E261st/EcR^M554fs embryos generally do not hatch.

(Bender et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

EcR^E261st, Sin3A^k07401 has lethal phenotype

(Tsai et al., 1999)

EcR^E261st, Sin3A^k07401 has visible phenotype

(Tsai et al., 1999)

Phenotype Manifest In

Other

Statement

Reference

EcR^E261st, Sin3A^k07401 has wing phenotype

(Tsai et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Genetic interaction between EcR^E261st and Sin3A^k07401 reported in FBrf0111507 is not evident when EcR^C300Y is combined with Sin3A⁰⁸²⁶⁹, suggesting that the original observed interaction could be due to background effects.

(Bodai, 2000.12.22)

Only 14% of EcR^E261st/Sin3A^k07401 flies derived from a cross of Sin3A^k07401 females to EcR^E261st males survive (significantly lower than the expected 33.3%). Escapers show delayed development and wing defects; the wings are held horizontally at a 45-90^o angle from the body axis. None of the EcR^E261st/Sin3A^k07401 progeny of a cross of EcR^E261st females to Sin3A^k07401 males survive to adulthood.

(Tsai et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

EcR^E261st

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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