FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\EcRB1.hs
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General Information
Symbol
Dmel\EcRB1.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0083499
Feature type
allele
Associated gene
Dmel\EcR
Associated Insertion(s)
Carried in Construct
P{hs-EcR.B1}
Also Known As
hs-EcR-B1, hs-EcR.B1
Key Links
Transgenic product class
wild_type
(Bender et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bender et al., 1997)
Mutagen
in vitro construct
(Bender et al., 1997)
Progenitor genotype
Carried in construct
P{hs-EcR.B1}
Cytology
Description

Construct: The EcR-B1 isoform is expressed under the control of a heat shock promoter.

(Bender et al., 1997)
Allele components
Component
Use(s)
Encoded product / tool
EcR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing EcRB1.hs have defects in the mushroom body α/β lobes: the lobes may appear slim.

      (Kucherenko et al., 2012)

      Expression of EcRB1.hs using heat shock results in germaria that are filled with supernumerary germline cells containing a single spectrosome in females. After 7 days of heat shock treatment, 84% of germaria contain dumbbell-shaped fusomes.

      (König et al., 2011)

      Heat induced expression of EcRB1.hs (using a single heat shock for 45 minutes at 37oC) results in more than 50% lethality if the heat shock is started between 5 hours before puparium formation to 0.5 hours after puparium formation.

      (Schubiger et al., 2003)

      Expression of EcRB1.hs in embryos does not result in a dorsal open phenotype.

      (Gritzan et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      EcRB1.hs is a suppressor of adult midgut phenotype of Lam14

      (Osouda et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of EcRB1.hs, following heat shock at 29oC, in Lam14 animals reduces the hypertrophy of the ventriculus.

      (Osouda et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      EcRB1.hs partially rescues EcRM554fs/EcRV559fs

      (Li and Bender, 2000)
      Comments

      Expression of EcRB1.hs via heat pulses every 12 hours during development can efficiently rescue EcRM554fs/EcRV559fs animals to the first larval instar stage (83% rescue).

      (Li and Bender, 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      EcRB1.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (8)