FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\foghkb.PB
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General Information
Symbol
Dmel\foghkb.PB
Species
D. melanogaster
Name
huckebein promoter construct of Barrett
FlyBase ID
FBal0085834
Feature type
allele
Associated gene
Dmel\fog
Associated Insertion(s)
Carried in Construct
P{hkb-fog.B}
Also Known As
hkb::fog
Key Links
Transgenic product class
wild_type
(Barrett et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Barrett et al., 1997)
Mutagen
in vitro construct
(Barrett et al., 1997)
Progenitor genotype
Carried in construct
P{hkb-fog.B}
Cytology
Description

A hkb enhancer element is fused upstream of a minimal Hsp70 promoter (-198bp to +195bp) driving fog expression.

(Barrett et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
hkb
Encoded product / tool
fog
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fog4, foghkb.PB exhibit motor axon defects in late stage 16 embryos, with particular problems in SNa bifurcation.

      fog4, foghkb.PB mutants display defects in SNa motor axon guidance. In most segments that display a phenotype, either the posterior or the anterior SNa branch is missing. Occasionally, extra anterior branches are observed. In rare cases, the entire SNa appears to stall at the bifurcation point.

      (Ratnaparkhi and Zinn, 2007)

      Embryos carrying foghkb.PB show a transient depression in the dorsal head region. The surfaces of the cells in this region show membrane blebbing and constrictions closely resembling those seen in cells along the ventral furrow of wild-type embryos. The nuclei of these cells have migrated from an apical to a basal location.

      (Barrett et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      foghkb.PB has embryonic head | dorsal phenotype, suppressible by RhoGEF21.1

      (Barrett et al., 1997)

      foghkb.PB has embryonic head | dorsal phenotype, suppressible by RhoGEF24.1

      (Barrett et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The depression in the dorsal head region is not seen in embryos carrying foghkb.PB which are derived from homozygous RhoGEF21.1 or RhoGEF24.1 female germline clones.

      (Barrett et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      foghkb.PB rescues fog4

      (Ratnaparkhi and Zinn, 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      foghkb.PB
      Name Synonyms
      huckebein promoter construct of Barrett
      (Barrett et al., 1997)
      Secondary FlyBase IDs
        References (4)