FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ras85DV12.ey
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General Information
Symbol
Dmel\Ras85DV12.ey
Species
D. melanogaster
Name
FlyBase ID
FBal0085935
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

A 3.4kb EcoRI ey enhancer fragment drives expression of a constitutively active form of Ras85D.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
model of  carcinoma
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eye imaginal discs of third instar larvae raised at 18oC are larger than normal, consistent with ectopic cell proliferation and hyperplastic growth, but the adult eyes are rough and slightly smaller than normal. When raised at 25oC the eye imaginal discs are dramatically larger than wild type. These animals survive as adults and have larger-than-normal eyes with protruding outgrowths of eye tissue and cuticle emanating from the posterior margin. Occasionally, rather than having larger eyes ventral portions or all of one eye may be missing. When raised at 29oC, larvae have no eye-antennal discs. These animals die as pharate adults and completely lack all head structures derived from the missing disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

Ras85DV12.ey has phenotype, suppressible by RafXS-2541

Additional Comments
Genetic Interactions
Statement
Reference

Phenotype can be partially suppressed by phlXS-2541 at 29oC, most mutants have head structures, some survive to adulthood with a limited amount of hyperplasia.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Ras85DV12.ey
Name Synonyms
Secondary FlyBase IDs
    References (1)