FlyBase Allele Report: Dmel\aos::vn[EGF.UAS]

General Information

Symbol

Dmel\aos::vn^EGF.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0089259

Feature type

allele

Associated gene

aos::vn

Associated Insertion(s)

Carried in Construct

P{UAS-vn-gil.EGF}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Schnepp et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-vn-gil.EGF}

Cytology

Description

vn cDNA lacking the EGF motif, a type 1 cDNA corresponding to nucleotides 1679-3980, is fused with fragment encoding the aos EGF motif.

(Schnepp et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

aos::vn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^69B

(Donaldson et al., 2004, Schnepp et al., 1998)

visible, with Scer\GAL4^ptc-559.1

(Donaldson et al., 2004)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^ptc-559.1

(Donaldson et al., 2004)

eye, with Scer\GAL4^69B

(Schnepp et al., 1998)

ommatidium, with Scer\GAL4^69B

(Schnepp et al., 1998)

wing | ectopic | posterior, with Scer\GAL4^ptc-559.1

(Wang et al., 2000)

wing pouch | ectopic | third instar larval stage, with Scer\GAL4^ptc.PU

(Recasens-Alvarez et al., 2017)

wing vein, with Scer\GAL4^69B

(Donaldson et al., 2004, Schnepp et al., 1998)

Detailed Description

Statement

Reference

The expression of aos::vn^EGF.Scer\UAS under the control of Scer\GAL4^ptc.PU induces ectopic wing structures in third instar larval wing discs, a compared to controls.

(Recasens-Alvarez et al., 2017)

Expression of argos::vn^EGF.Scer\UAS under the control of Scer\GAL4^69B results in loss of wing veins. 92% of wings lack the anterior crossvein in flies expressing argos::vn^EGF.Scer\UAS under the control of Scer\GAL4^ptc-559.1.

(Donaldson et al., 2004)

The expression of argos::vn^EGF.Scer\UAS driven by Scer\GAL4^ptc-559.1 produces a "four wing fly". The ectopic wings appear below the normal wings in mirror symmetry and are composed mainly of posterior structures. The ectopic wings do include some anterior wing tissue that can be recognised as such by margin bristles and sensilla characteristic of the third wing vein.

(Wang et al., 2000)

Scer\GAL4^69B-mediated expression causes a mild or moderate extra-vein phenotype. Wing is also smaller than wild type as vein cells that replace inter vein cells are more compact. Mediated expression causes a rough eye phenotype: eyes are smaller than wild type and some ommatidia are fused.

(Schnepp et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

aos::vn^EGF.Scer\UAS

aos::vn^EGF.UAS

argos::vn^EGF.Scer\UAS

argos::vn^EGF.UAS

gil::vn^EGF.UAS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close