FlyBase Allele Report: Dmel\eya[D3]

General Information

Symbol

Dmel\eya^D3

Species

D. melanogaster

Name

FlyBase ID

FBal0089400

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bonini et al., 1998)

Progenitor genotype

Cytology

Description

Carries an indel in exon 5 where a TT doublet is substituted by CCCCCCCCCG, creating a frameshift at F737 and resulting in a C-terminus of 48 random amino acids in place of the usual 23.

(Tian et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:6,528,083..6,528,084 [-]

Comment:

Carries an indel in exon 5 where a TT doublet is substituted by CCCCCCCCCG, creating a frameshift at F737 and resulting in a C-terminus of 48 random amino acids in place of the usual 23.

Inserted_sequence:

CCCCCCCCCG

(Tian et al., 2019)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with eya²)

(Tian et al., 2019)

lethal | recessive

(Bonini et al., 1998, Leiserson et al., 1998)

visible | adult stage (with eya²)

(Tian et al., 2019)

visible | adult stage (with eya⁴)

(Tian et al., 2019)

visible | recessive

(Bonini et al., 1998, Leiserson et al., 1998)

Phenotype Manifest In

eye

(Bonini et al., 1998, Leiserson et al., 1998)

eye (with eya²)

(Tian et al., 2019)

eye (with eya⁴)

(Tian et al., 2019)

Detailed Description

Statement

Reference

eya²/eya⁴ and eya²/eya³ adults exhibit significantly higher number of ommatidia in the eye than eya²/eya^D3 adults.

(Tian et al., 2019)

eya^D3/eya¹ flies are eyeless. eya^D3/eya³ flies may be eyeless, or may have eyes that are up to less than 3/4 normal size.

(Bonini et al., 1998)

eya^D3/Df(2L)eya¹⁰ embryos fail to hatch. eya^D3/eya^E3 embryos animals do not survive to adulthood. eya^D3/eya⁴ flies are eyeless.

(Leiserson et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

eya²

(Tian et al., 2019)

Fails to complement

eya⁴

(Tian et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cli^D3

eya^D3

(Tian et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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