FlyBase Allele Report: Dmel\eya[4]

General Information

Symbol

Dmel\eya⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0030761

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

I{}eya⁴

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Bonini et al., 1998, Leiserson et al., 1994)

Progenitor genotype

Associated Insertion(s)

I{}eya⁴

Cytology

Description

I-element insertion into the 5' untranslated region of the type I eya transcript. The insertion duplicates 8bp of genomic sequence.

(Zimmerman et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with eya¹)

(Tian et al., 2019)

abnormal size | adult stage (with eya²)

(Tian et al., 2019)

abnormal size | adult stage (with eya^cs)

(Tian et al., 2019)

abnormal size | adult stage (with In(2LR)ETD2.2)

(Tian et al., 2019)

female fertile

(Bonini et al., 1998)

viable

(Tian et al., 2019, Zimmerman et al., 2000, Bonini et al., 1998, Leiserson et al., 1998)

visible | adult stage

(Tian et al., 2019)

visible | adult stage (with eya¹)

(Tian et al., 2019)

visible | adult stage (with eya²)

(Tian et al., 2019)

visible | adult stage (with eya³)

(Tian et al., 2019)

visible | adult stage (with eya^54C2)

(Tian et al., 2019)

visible | adult stage (with eya^cli-IID)

(Tian et al., 2019)

visible | adult stage (with eya^cs)

(Tian et al., 2019)

visible | adult stage (with eya^D3)

(Tian et al., 2019)

visible | adult stage (with eya^E1)

(Tian et al., 2019)

visible | adult stage (with eya^E4)

(Tian et al., 2019)

visible | adult stage (with In(2LR)ETD2.2)

(Tian et al., 2019)

visible | recessive

(Zimmerman et al., 2000, Bonini et al., 1998, Leiserson et al., 1998, Bonini et al., 1993, Eissenberg and Ryerse, 1991)

Phenotype Manifest In

eye

(Tian et al., 2019, Zimmerman et al., 2000, Bonini et al., 1998, Leiserson et al., 1998, Leiserson et al., 1994, Eissenberg and Ryerse, 1991)

eye (with eya¹)

(Tian et al., 2019)

eye (with eya²)

(Tian et al., 2019)

eye (with eya³)

(Tian et al., 2019)

eye (with eya^54C2)

(Tian et al., 2019)

eye (with eya^cli-IID)

(Tian et al., 2019)

eye (with eya^cs)

(Tian et al., 2019)

eye (with eya^D3)

(Tian et al., 2019)

eye (with eya^E1)

(Tian et al., 2019)

eye (with eya^E4)

(Tian et al., 2019)

eye (with In(2LR)ETD2.2)

(Tian et al., 2019)

eye-antennal disc

(Eissenberg and Ryerse, 1991)

ocellus

(Zimmerman et al., 2000, Eissenberg and Ryerse, 1991)

ommatidium

(Eissenberg and Ryerse, 1991)

vertical bristle 2

(Eissenberg and Ryerse, 1991)

Detailed Description

Statement

Reference

eya⁴/eya⁴, eya³/eya⁴, eya^E1/eya⁴, eya^E4/eya⁴, and eya^cli-IID/eya⁴ adults are eyeless. eya²/eya⁴ adults exhibit smaller eyes compared to controls.

eya¹/eya³ and eya¹/eya⁴ adults do not exhibit any difference in the number of ommatidia in the eye while adults containing either genotype exhibit significantly higher number of ommatidia in the eye than eya¹/eya^E1, eya¹/eya^E4 and eya¹/eya^cli-IID adults.

eya²/eya⁴ adults exhibit significantly higher number of ommatidia in the eye than eya²/eya^E1, eya²/eya^E4, eya²/eya^cli-IID eya²/eya^54C2 and eya²/eya^D3 adults.

eya^cs/eya⁴ adults exhibit greater number of ommatidia than eya^cs/eya^cs, eya^cs/eya^cli-IID, eya^cs/eya^E4 and eya^cs/T(2;3;4)ETD4.3 adults.

(Tian et al., 2019)

Homozygotes have greatly reduced eyes and reduced ocelli.

(Zimmerman et al., 2000)

eya⁴/eya¹ flies have eyes that are between 1/4 and less than 3/4 normal size. eya⁴/eya³ flies may be eyeless, or may have eyes that are less than 1/4 normal size. eya⁴/eya³ females are fertile.

(Bonini et al., 1998)

eya⁴/eya^E3 flies are viable, and have eyes which range from 1/2 to less than normal size. Homozygous flies have eyes which are less than 1/2 normal size. Transheterozygotes in combination with eya¹, eya², eya³, eya^E6, eya^E11, eya^E4, eya^E7, eya^D1, eya^E9 or eya^E2 have smaller eyes than normal. Transheterozygotes in combination with eya^E12, eya^E1, eya^D5, eya^cli-IID, eya^E8, eya^E5, eya^E10, eya^D4, eya^Z283, eya^D2, eya^D3, eya^D6 or eya^D7 are eyeless.

(Leiserson et al., 1998)

Homozygotes have severely reduced eyes. eya²/eya⁴ heterozygous flies have 3/4 sized eyes.

(Leiserson et al., 1994)

Ocelli are missing, and the posterior vertical bristles of the head are truncated with frayed ends. Eyes have a variable phenotype, ranging from all eye tissue absent, with cuticle containing occasional hairs or bristles occupying the space normally occupied by the ommatidia, through streaks of red-pigmented cuticle with no eye facets present, to patches of red-pigmented cuticle occupying 10-25% of the wild-type eye area, and 10-25 facets present. Eye discs from late third instar larvae show extensive areas of dead cells. Transheterozygotes with eya¹ have reduced eyes with fewer facets than normal and the facets are disorganised. The posterior vertical bristles of the head are truncated with frayed ends.

(Eissenberg and Ryerse, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Transheterozygotes with dpp^d-blk and so^unspecified are normal.

(Eissenberg and Ryerse, 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

eya¹

(Tian et al., 2019)

eya²

(Tian et al., 2019)

Rescued by

eya⁴ is rescued by Scer\GAL4^unspecified/eya^UAS.cBa

(Zimmerman et al., 2000)

eya⁴ is rescued by Scer\GAL4^unspecified/eya^UAS.cBb

(Zimmerman et al., 2000)

eya⁴ is rescued by eya^II.hs

(Leiserson et al., 1998)

eya⁴ is rescued by eya^I.hs

(Leiserson et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Eisenberg and Ryerse.

(Bonini et al., 1993)

Comments

eya³ and eya⁴ form an intragenic complementation group that interacts with eya¹ and eya².

(Leiserson et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

cli^eya-4

ey-2

(Eissenberg and Ryerse, 1991)

ey-2^unspecified

eya⁴

(Tian et al., 2019)

Name Synonyms

Secondary FlyBase IDs

FBal0051586

References (8)

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