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General Information
Symbol
Dmel\eya3
Species
D. melanogaster
Name
FlyBase ID
FBal0030760
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
eya3cs
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

roo insertion into the 5' untranslated region of the type I eya transcript. The insertion duplicates 5bp of genomic sequence.

Insertion components
roo{}eya3
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

eya3/eya4 adults are eyeless.

eya1/eya3 and eya1/eya4 adults do not exhibit any differences in the number of ommatidia in the eye while adults containing either genotype exhibit significantly higher number of ommatidia in the eye than eya1/eyaE1 eya1/eyaE4 and eya1/eyacli-IID adults.

eya2/eya3 adults exhibit significantly higher number of ommatidia in the eye than eya2/eyaE1, eya2/eyaE4, eya2/eya54C2 and eya2/eyaD3 but not eya2/eyacli-IID adults.

eyacs/eya3 adults exhibit greater number of ommatidia than eyacs/eyacs, eyacs/eyacli-IID, eyacs/eyaE4 and eyacs/T(2;3;4)ETD4.3 adults.

Less eya3 homozygotes eclose than wild-type, and those that do have severely reduced eyes, and are both male and female sterile. The testes of eya3/Df(2L)eya10 flies are shorter and thinner than wild-type, and are generally devoid of cells in the postmeiotic stages of spermatogenesis. Instead, the lumen's of these testes accumulate rounded up spermatocyte cysts with varying degrees of expressivity. Large clusters of these spermatocytes are apoptotic (assessed by acridine orange staining). Degenerating spermatocytes do not lose their encapsulation by somatic cells.

eya3/eyaE(P)10 have egg chambers which contain abnormal germline cells. In extreme cases, ovarian development ceases in the germarium and the germarium appears swollen compared to wild type.

Homozygotes have reduced eyes and ocelli. Cold-sensitive allele.

Homozygotes may be eyeless, or may have eyes that are up to less than 3/4 normal size. Ocelli are also lost. eya3/eya1 flies have eyes that are between 3/4 and less than normal size.

Female fertile in combination with eya1, eya2, eya4 or eyacli-IID. Female sterile in combination with eyaD1.

Produces eyeless flies in combination with eyaE1, eyaE2, eyaE5, eyaE8, eyaE10 or eyacli-IID. Produces flies which are either eyeless or have reduced eyes in combination with eya4, eyaE4, eyaZ283, eyaD1, eyaD2, eyaD3, eyaD4, eyaD5, eyaD6 or eyaD7. Produces flies with reduced eyes in combination with eyaE6, eyaE9 or eyaE11.

eya3/eyaE3 flies are viable, and have eyes which range from 1/2 to less than normal size. eya3/eya4 flies have eyes which are less than 1/2 normal size.

Compound eyes are reduced in size, having approximately 25% of the wild-type number of ommatidia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

eya3 and eya4 form an intragenic complementation group that interacts with eya1 and eya2.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)