FlyBase Allele Report: Dmel\JIL-1[h9]

General Information

Symbol

Dmel\JIL-1^h9

Species

D. melanogaster

Name

FlyBase ID

FBal0089627

Feature type

allele

Associated gene

Dmel\JIL-1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

Df(3L)h9

Cytology

Description

Df(3L)h9 removes the 3' end of JIL-1, removing sequences beyond nucleotide 3398 of JIL-1. This results in an in-frame stop codon after amino acid 795.

(Zhang et al., 2003)

Deletion removes the C-terminal protein sequence.

(Jin et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with JIL-1^z2)

(Zhang et al., 2003)

lethal - all die during embryonic stage | maternal effect (with JIL-1^z2)

(Zhang et al., 2003)

some die during embryonic stage | maternal effect (with JIL-1^z2)

(Zhang et al., 2003)

suppressor of variegation (with JIL-1^z2), with In(1)w^m4

(Lerach et al., 2006)

Phenotype Manifest In

egg (with JIL-1^z2)

(Zhang et al., 2003)

egg chamber (with JIL-1^z2)

(Zhang et al., 2003)

nurse cell (with JIL-1^z2)

(Zhang et al., 2003)

oocyte nucleus (with JIL-1^z2)

(Zhang et al., 2003)

ovariole (with JIL-1^z2)

(Zhang et al., 2003)

ovary (with JIL-1^z2)

(Zhang et al., 2003)

polytene chromosome (with JIL-1^z2)

(Zhang et al., 2006, Zhang et al., 2003)

polytene chromosome band | male (with JIL-1^z2)

(Zhang et al., 2006)

polytene chromosome interband (with JIL-1^z2)

(Zhang et al., 2003)

Detailed Description

Statement

Reference

JIL-1^z2/JIL-1^h9 mutants the morphology of the polytene chromosomes is perturbed with coiled and compacted chromosome arms. The male X polytene chromosome shows the most extreme version of this phenotype with no coherent bands visible.

(Zhang et al., 2006)

0% of embryos derived from JIL-1^z2/JIL-1^h9 females mated to wild-type males hatch. Heterozygous ovaries are indistinguishable from wild-type in size. JIL-1^z2/JIL-1^h9 animals that survive to adulthood are sterile and females produce significantly fewer eggs than normal. JIL-1^z2/JIL-1^h9 ovaries are significantly decreased in size compared to wild type, consisting primarily of connective tissue with little or no apparent ovariole development, although in some cases ovary tissue develops to some degree. In those females with some ovary development, a range of egg chamber defects are seen. The most common consists of egg chambers with a reduction in the number of nurse cells and no apparent oocyte nucleus. In other cases cell nuclei within the egg chamber appear to fragment of fail to undergo DNA amplification. In a few cases, egg chambers containing an increased number of nurse cells are seen. In all cases, other ovarioles in the same ovary often appear empty with no egg chamber development.

(Zhang et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

JIL-1^z2/JIL-1^h9 is a suppressor | partially of enhancer of variegation | dominant phenotype of E(var)2-1¹, In(1)w^m4

(Lerach et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

General trend from least to most viable is: JIL-1^z2 < JIL-1^h9 < JIL-1^z60 < JIL-1^EP3657 < JIL-1^z28 ~ JIL-1^Scim.

(Zhang et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

JIL-1^h9

(Silva-Sousa and Casacuberta, 2013, Lerach et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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