FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\putD18
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General Information
Symbol
Dmel\putD18
Species
D. melanogaster
Name
FlyBase ID
FBal0090167
Feature type
allele
Associated gene
Dmel\put
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl nitrosourea
(Chen et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: E378V.

(Chen et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:14,621,512..14,621,512 [-]
Nucleotide change:

A14621512T

Amino acid change:

E378V | put-PA; E378V | put-PB; E378V | put-PC

Reported amino acid change:

E378V|FBrf0102634

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Chen et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal in transheterozygous combination with put135.

      (Chen et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Other
      Statement
      Reference

      putD18, tkv6 has scutum phenotype

      (Chen et al., 1998)

      putD18, tkv6 has leg phenotype

      (Chen et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      putD18 dominantly enhances the tkv6 phenotype; tkv6 homozygotes have a normal notum and legs, but the presence of one copy of putD18 results in defects in the notum and legs. Double heterozygotes with Df(2L)tkv2 may show imaginal disc development defects. No interaction with Med4 is seen in double heterozygous flies.

      (Chen et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: Dominant enhancer of the tkv6 phenotype.

      (Chen et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      D18
      (Chen et al., 1998)
      putD18
      Name Synonyms
      Secondary FlyBase IDs
        References (1)