FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Med17
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General Information
Symbol
Dmel\Med17
Species
D. melanogaster
Name
FlyBase ID
FBal0090594
Feature type
allele
Associated gene
Dmel\Med
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hudson et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: P715T.

(Hudson et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,614,806..31,614,806 [+]
Nucleotide change:

C31614806A

Amino acid change:

P741T | Med-PA; P667T | Med-PB; P741T | Med-PC

Reported amino acid change:

P715T

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

(Hudson et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  muscular dystrophy
      modeled by Scgδ840
      (Goldstein et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous adults do not have any obvious phenotypic abnormalities. 98% of embryos derived from homozygous females hatch.

      (Hudson et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Med17/Med[+] is a suppressor of abnormal locomotor behavior | adult stage phenotype of Scgδ840

      (Goldstein et al., 2011)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Med17/Med[+] is an enhancer of phenotype of dpphr4

      (Hudson et al., 1998)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Animals derived from homozygous Med17 females mated to dpphr4/+ males show strong lethality (less than 5% of the expected number survive).

      (Stinchfield et al., 2012)

      The severe loss of climbing ability in a negative geotaxis assay which is seen in Scgδ840 mutants is suppressed if the flies are also carrying Med17/+.

      (Goldstein et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Med17
      (Stinchfield et al., 2012)
      Medea17
      (Goldstein et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)