FB2026_02 , released June 18, 2026
Allele: Dmel\tra2ΔM1
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General Information
Symbol
Dmel\tra2ΔM1
Species
D. melanogaster
Name
FlyBase ID
FBal0091138
Feature type
allele
Associated gene
Dmel\tra2
Associated Insertion(s)
Carried in Construct
P{tra2.ΔM1}
Key Links
Transgenic product class
wild_type
(McGuffin et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(McGuffin et al., 1998)
Mutagen
in vitro construct
(McGuffin et al., 1998)
Progenitor genotype
tra2+t3.6
(McGuffin et al., 1998)
Carried in construct
P{tra2.ΔM1}
Cytology
Description

Deletion of the M1 intron.

(McGuffin et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
tra2
Encoded product / tool
tra2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Single dose in a tra2/+ background does not substantially affect male fertility. Two or three doses in a tra2/+ background causes a quantitative reduction in male fertility. Males carrying four doses in a tra2/+ background are uniformly sterile, due to a defect in spermatogenesis. External appearance is completely male. Gonial cells, spermatocytes, meiotic stages and mature spermatids appear normal. Bundles of spermatids are not tightly coiled as they would be in wild type. Mature sperm fail to migrate to the seminal vesicle, indicating amotility. Sperm are never observed in the spermathaecae or seminal receptacles.

      (McGuffin et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      tra2ΔM1 partially rescues tra2B

      (McGuffin et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Functional in both the female soma and male germline.

      (McGuffin et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tra2ΔM1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)