FlyBase Allele Report: Dmel\qua[6-396]

General Information

Symbol

Dmel\qua^6-396

Species

D. melanogaster

Name

FlyBase ID

FBal0091477

Feature type

allele

Associated gene

Dmel\qua

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bakken, 1973)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | recessive

(Bakken, 1973)

female sterile | recessive

(Bloomington Drosophila Stock Center, 1998.9.22, Bakken, 1973)

Phenotype Manifest In

actin filament bundle | oogenesis (with qua^8-1062)

(Groen et al., 2015)

dorsal appendage

(Bakken, 1973)

egg

(Bakken, 1973)

female reproductive system

(Bakken, 1973)

nucleolus | oogenesis (with qua^8-1062)

(Groen et al., 2015)

nurse cell | oogenesis (with qua^8-1062)

(Groen et al., 2015)

ovary

(Bloomington Drosophila Stock Center, 1998.9.22)

spindle

(Bakken, 1973)

wing hair (with qua¹)

(Guild et al., 2005)

Detailed Description

Statement

Reference

qua^6-396/qua^8-1062 nurse cells have a mildly dispersed nucleolus during oogenesis. Additionally, their inability to form cytoplasmic actin bundles and to complete dumping by stage 13, results in larger nurse cells and a smaller oocyte than controls.

(Groen et al., 2015)

The wing hairs of qua¹/qua^6-396 mutants are 23% longer than wild-type hairs.

(Guild et al., 2005)

Classic dumpless phenotype.

(Bloomington Drosophila Stock Center, 1998.9.22)

Group I phenotype: females have normal internal genitalia and lay eggs which are fertilized. Eggs are short with truncated anterior tip, short fat chorionic appendages and normal micropyle. They are the size and shape of stage 11 oocytes. Eggs show mitotic spindle difficulties.

(Bakken, 1973)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions