FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ipp3
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General Information
Symbol
Dmel\Ipp3
Species
D. melanogaster
Name
FlyBase ID
FBal0091737
Feature type
allele
Associated gene
Dmel\Ipp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Acharya et al., 1998)
Progenitor genotype
Cytology
Description

11bp insertion at position 902, resulting in a frameshift at amino acid residue 273.

(Acharya et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3R:13,960,022..13,960,023 [+]
Comment:

Site of an 11 nucleotide insertion which causes a frameshift at amino acid 273; exact site of insertion not reported.

(Acharya et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by PsnI2
      (McBride et al., 2010)
      modeled by PsnB3
      (McBride et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ipp3/+ 30-day-old adult males display learning defects as they fail to demonstrate significant decrease in courtship activity when paired with an mated unreceptive female but their short-term (60 min) memory is not impaired.

      (McBride et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Ipp3 has abnormal learning | male | adult stage phenotype, suppressible by PsnB3/Psn[+]

      (McBride et al., 2010)

      Ipp3 has abnormal learning | male | adult stage phenotype, suppressible by PsnI2/Psn[+]

      (McBride et al., 2010)
      Suppressor of
      Statement
      Reference

      Ipp3/Ipp[+] is a suppressor of abnormal learning | male | adult stage | progressive phenotype of PsnB3

      (McBride et al., 2010)

      Ipp3/Ipp[+] is a suppressor of abnormal memory | male | adult stage | progressive phenotype of PsnB3

      (McBride et al., 2010)

      Ipp3/Ipp[+] is a suppressor of abnormal learning | male | adult stage | progressive phenotype of PsnI2

      (McBride et al., 2010)

      Ipp3/Ipp[+] is a suppressor of abnormal memory | male | adult stage | progressive phenotype of PsnI2

      (McBride et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The learning defects (measured in a courtship behavior assay) observed in either the PsnB3, PsnI2 or the Ipp3 single heterozygote 30 day-old males are suppressed in both the PsnB3/+;Ipp3/+ and the PsnI2/+;Ipp3/+ double heterozygotes. Combination with a single copy of Ipp3 can also restore the short-term memory defects characteristic for either PsnB3 or PsnI2 aged heterozygote males.

      (McBride et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      IPPase3
      (McBride et al., 2010)
      Ipp3
      ipp3
      (Acharya et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)