FlyBase Allele Report: Dmel\put[ΔI.UAS]

General Information

Symbol

Dmel\put^ΔI.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0092541

Feature type

allele

Associated gene

Dmel\put

Associated Insertion(s)

Carried in Construct

P{UAS-put.ΔI}

Also Known As

UAS-putΔI, UAS-put^DN

Key Links

Transgenic product class

dominant_negative_variant

(Haerry et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Haerry et al., 1998)

Mutagen

in vitro construct

(Haerry et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-put.ΔI}

Cytology

Description

A dominant negative form of put, lacking part of the kinase domain (stop codon after amino acid residue I353) is expressed under the control of UAS regulatory sequences.

(Haerry et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

put

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^RapGAP1-OK6

(Parker et al., 2006)

visible, with Scer\GAL4^A9

(Haerry et al., 1998)

visible, with Scer\GAL4^ptc-559.1

(Haerry et al., 1998)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^ptc-559.1

(Haerry et al., 1998)

larval intersegmental nerve, with Scer\GAL4^RapGAP1-OK6

(Parker et al., 2006)

wing, with Scer\GAL4^A9

(Haerry et al., 1998)

wing vein, with Scer\GAL4^en.PU

(Yan et al., 2009)

wing vein L2, with Scer\GAL4^A9

(Haerry et al., 1998)

wing vein L3, with Scer\GAL4^A9

(Haerry et al., 1998)

wing vein L4, with Scer\GAL4^A9

(Haerry et al., 1998)

wing vein L5, with Scer\GAL4^A9

(Haerry et al., 1998)

Detailed Description

Statement

Reference

Expression of put^ΔI.Scer\UAS in embryos, under the control of Scer\GAL4^OK6, results in ISNb pathfinding defects in 33% of hemisegments.

(Parker et al., 2006)

Flies expressing put^ΔI.Scer\UAS under the control of Scer\GAL4^A9 have small wings with fusion of veins L2 with L3 and L4 with L5. Flies expressing put^ΔI.Scer\UAS under the control of Scer\GAL4^ptc-559.1 lack the anterior crossvein.

(Haerry et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

put^ΔI.UAS, Scer\GAL4^hs.PU is a suppressor of wing vein | ectopic phenotype of Raf^UAS.F179, Scer\GAL4^hs.PU

(Yan et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

put^ΔI.Scer\UAS

put^ΔI.UAS

putΔI

(Haerry et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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