FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shaVB13
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General Information
Symbol
Dmel\shaVB13
Species
D. melanogaster
Name
FlyBase ID
FBal0092908
Feature type
allele
Associated gene
Dmel\sha
Associated Insertion(s)
Carried in Construct
Also Known As
kojVB13
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    heat sensitive loss of function allele

    (He and Adler, 2002)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: P195L.

    (Ren et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:11,331,161..11,331,161 [+]
    Nucleotide change:

    C11331161T

    Amino acid change:

    P195L | sha-PA; P202L | sha-PB; P195L | sha-PC

    Reported amino acid change:

    P195L

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Ren et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        1st posterior cell | ventral & wing hair

        (Ren et al., 2006)

        3rd posterior cell | dorsal & wing hair

        (Ren et al., 2006)

        3rd posterior cell | dorsal & wing hair | somatic clone

        (Ren et al., 2006)

        arista | heat sensitive

        (He and Adler, 2002)

        wing hair

        (Taylor et al., 1998)

        wing hair | heat sensitive

        (He and Adler, 2002)
        Detailed Description
        Statement
        Reference

        Hairs on the dorsal surface of the centre of the E region of the wing are slightly finer and more elevated than normal in homozygous flies raised at 25oC.

        Cells in homozygous clones on the dorsal surface of the centre of the E region of the wing do not produce hairs.

        (Ren et al., 2006)

        Arista laterals are shorter than normal in mutant flies and are often split. At 18oC, the phenotype is weak in shaVB13 hemizygotes, with less than 10% of laterals being split, while at 29oC more than 40% of laterals are branched. The temperature sensitive period is close to when laterals initiate. shaVB13 hemizygotes have a variable wing hair phenotype, ranging from cells that produce no wing hair, to cells that produce a number of short hairs to cells that produce a normal hair. Split wing hairs are seen, but are not as common as independent multiple hairs. The temperature sensitive period is the time of hair initiation.

        (He and Adler, 2002)

        Some cells form multiple split and shortened hairs and others have no hair at all.

        (Taylor et al., 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Statement
        Reference

        shaVB13, tow[+]/tow754 has visible phenotype

        (Chung et al., 2007)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        shaVB13 has wing hair phenotype, enhanceable by fz25

        (Ren et al., 2006)

        shaVB13 has wing hair phenotype, enhanceable by dsh1

        (Ren et al., 2006)

        shaVB13 has wing hair phenotype, enhanceable by in1

        (Ren et al., 2006)

        shaVB13 has wing hair phenotype, enhanceable by frtz2

        (Ren et al., 2006)

        shaVB13 has wing hair phenotype, enhanceable by VangTbs42

        (Ren et al., 2006)
        Other
        Statement
        Reference

        shaVB13, tow[+]/tow754 has wing hair phenotype

        (Chung et al., 2007)

        shaVB13, tow[+]/tow754 has wing hair | increased number phenotype

        (Chung et al., 2007)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        tow754/+ increases the number of small and multiple wing hairs seen in a shaVB13/shaVB13 background.

        (Chung et al., 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        shaVB13 is partially rescued by Scer\GAL4Act.PU/shaUAS.GFP

        (Ren et al., 2006)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        kojVB13
        (He and Adler, 2002, Taylor et al., 1998)
        shaVB13
        (Chung et al., 2007, Ren et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)