FlyBase Allele Report: Dmel\tup[ΔHD.UAS]

General Information

Symbol

Dmel\tup^ΔHD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0092914

Feature type

allele

Associated gene

Dmel\tup

Associated Insertion(s)

Carried in Construct

P{UAS-isl.ΔHD}

Key Links

Transgenic product class

inframe_deletion

(O'Keefe et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(O'Keefe et al., 1998)

Mutagen

in vitro construct

(O'Keefe et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-isl.ΔHD}

Cytology

Description

A truncated form of tup (amino acids 1 to 226, lacks the homeodomain) is expressed under the control of UAS regulatory sequences.

(O'Keefe et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

tup

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(O'Keefe et al., 1998)

Phenotype Manifest In

dorsocentral bristle, with Scer\GAL4^pnr-MD237

(Biryukova and Heitzler, 2005)

scutellar bristle, with Scer\GAL4^pnr-MD237

(Biryukova and Heitzler, 2005)

thorax, with Scer\GAL4^pnr-MD237

(Biryukova and Heitzler, 2005)

wing, with Scer\GAL4^ap-md544

(O'Keefe et al., 1998)

Detailed Description

Statement

Reference

Expression of tup^{ΔHD.Scer\UAS}, under the control of Scer\GAL4^pnr-MD237, results in a slight cleft in the thorax and a lack of dorsocentral and scutellar bristles.

(Biryukova and Heitzler, 2005)

Flies expressing tup^{ΔHD.Scer\UAS} under the control of Scer\GAL4^ap-md544 have blistered wings with margin defects.

(O'Keefe et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ap-md544, tup^ΔHD.UAS has visible phenotype, suppressible by ap^UAS.cOa/Scer\GAL4^ap-md544

(O'Keefe et al., 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ap-md544, tup^ΔHD.UAS has wing phenotype, suppressible by ap^UAS.cOa/Scer\GAL4^ap-md544

(O'Keefe et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The wing phenotype caused by expression of tup^{ΔHD.Scer\UAS} under the control of Scer\GAL4^ap-md544 is completely suppressed if the flies are also co-expressing ap^Scer\UAS.cOa.

(O'Keefe et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

isl^ΔHD.UAS

tup^{ΔHD.Scer\UAS}

tup^ΔHD.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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