FB2026_02 , released June 18, 2026
Allele: Ecol\lacZUAS.O.Tag:MT(btau)
Open Close
General Information
Symbol
Ecol\lacZUAS.O.Tag:MT(btau)
Species
E. coli
Name
FlyBase ID
FBal0093135
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{UAS-lacZ.btau.YES}
P{UAS-tau-lacZ.O}
Also Known As
UAS-tau-lacZ, UAS-tlacZ
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lee and Luo, 1999, O'Keefe et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-lacZ.btau.YES}
P{UAS-tau-lacZ.O}
Cytology
Description

The expression of a Btau\MAPT-lacZ fusion gene is governed by UAS regulatory sequences.

(Lee and Luo, 1999)

UAS regulatory sequences drive expression of a Btau\MAPT-lacZ fusion gene.

(O'Keefe et al., 1998)

5.4kb EcoRI fragment containing a Btau\MAPT-lacZ fusion gene is expressed under the control of UASt regulatory sequences.

(Callahan et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
UASt
Encoded product / tool
lacZ
Tagged with
Tag:MT(btau)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference

      ScerGAL4-targeted reporter: expression of EcollacZ reflects action of enhancer/promoter elements driving GAL4 in the same cell.Product localized to microtubules; allows visualization of cell body, axons and other projections.

      (O'Keefe et al., 1998)

      ScerGAL4-targeted reporter; β-galactosidase distribution reflects action of enhancer/promoter elements driving GAL4 in the same cell.Product localized to microtubules: carries binding domain of BtauMAPT microtubule-associated protein.

      (O'Keefe et al., 1998)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ecol\lacZScer\UAS.O.T:Btau\MAPT under the control of Scer\GAL4smid-C161 results in defects in the axon projections in the prothoracic neuromere in adults. Bilateral loss of the medial projection, abnormal axon bundling and under-elaboration of axonal projections is seen.

      (Williams et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Btau\MAPTScer\UAS.O.T:Ecol\lacZ
      Ecol\lacZScer\UAS.O.T:Btau\MAPT
      Ecol\lacZUAS.O.Tag:MT(btau)
      UAS-tau LacZ
      (McGovern and Seeger, 2003)
      UAS-tau-lacZ
      (Herzig et al., 2001)
      btauUAS.O.T:lacZ
      Name Synonyms
      Secondary FlyBase IDs
        References (27)