FlyBase Allele Report: Hsap\LHX2[UAS.cRa]

General Information

Symbol

Hsap\LHX2^UAS.cRa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Rincon-Limas

FlyBase ID

FBal0093283

Feature type

allele

Associated gene

Hsap\LHX2

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\LHX2.R}

Key Links

Transgenic product class

cDNA

(Rincon-Limas et al., 1999)

wild_type

(Rincon-Limas et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Rincon-Limas et al., 1999)

wild_type

(Rincon-Limas et al., 1999)

Mutagen

in vitro construct

(Rodriguez-Esteban et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-Hsap\LHX2.R}

Cytology

Description

A 2kb Hsap\LHX2 cDNA is expressed under the control of UAS regulatory sequences.

(Rincon-Limas et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\LHX2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^32B

(Rincon-Limas et al., 1999)

visible, with Scer\GAL4^71B

(Rodriguez-Esteban et al., 1998)

visible, with Scer\GAL4^ptc-559.1

(Rincon-Limas et al., 1999)

Phenotype Manifest In

wing, with Scer\GAL4^32B

(Rincon-Limas et al., 1999)

wing, with Scer\GAL4^71B

(Rodriguez-Esteban et al., 1998)

wing, with Scer\GAL4^ptc-559.1

(Rincon-Limas et al., 1999)

Detailed Description

Statement

Reference

Expression of ap^Scer\UAS.cRa under the control of Scer\GAL4^ptc-559.1 or Scer\GAL4^32B results in severe wing defects which are virtually indistinguishable from the severe wing defects caused by expression of Hsap\LHX2^Scer\UAS.cRa under the control of Scer\GAL4^ptc-559.1 or Scer\GAL4^32B respectively.

(Rincon-Limas et al., 1999)

Flies expressing Hsap\LHX2^Scer\UAS.cRa under the control of Scer\GAL4^71B show ablation of the distal part of the wing.

(Rodriguez-Esteban et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/Hsap\LHX2^UAS.cRa is a suppressor of visible phenotype of ap^md544/ap^UGO35

(Rincon-Limas et al., 1999)

Scer\GAL4^ap-md544/Hsap\LHX2^UAS.cRa is a suppressor of sterile phenotype of ap^md544/ap^UGO35

(Rincon-Limas et al., 1999)

Scer\GAL4^ap-md544/Hsap\LHX2^UAS.cRa is a suppressor of short lived phenotype of ap^md544/ap^UGO35

(Rincon-Limas et al., 1999)

Other

Statement

Reference

Hsap\LHX2^UAS.cRa, Scer\GAL4^ap-md544, ap^md544/ap^UGO35 has visible phenotype

(Rincon-Limas et al., 1999)

Hsap\LHX2^UAS.cRa, Scer\GAL4^ap-md544, ap^UGO35 has visible | recessive phenotype

(Rincon-Limas et al., 1999)

Hsap\LHX2^UAS.cRa, Scer\GAL4^ap-md544, ap^md544 has visible | recessive phenotype

(Rincon-Limas et al., 1999)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/Hsap\LHX2^UAS.cRa is a suppressor of wing phenotype of ap^md544/ap^UGO35

(Rincon-Limas et al., 1999)

Scer\GAL4^ap-md544/Hsap\LHX2^UAS.cRa is a suppressor of haltere phenotype of ap^md544/ap^UGO35

(Rincon-Limas et al., 1999)

Scer\GAL4^ap-md544/Hsap\LHX2^UAS.cRa is a suppressor of scutellum phenotype of ap^md544/ap^UGO35

(Rincon-Limas et al., 1999)

Other

Statement

Reference

Hsap\LHX2^UAS.cRa, Scer\GAL4^ap-md544, ap^md544/ap^UGO35 has scutellar bristle phenotype

(Rincon-Limas et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Rescues the sterility, reduced lifespan, wing, haltere and scutellum phenotypes of ap^md544/ap^UGO35 flies when expressed under the control of Scer\GAL4^ap-md544. The rescued flies often develop one to two extra bristles in the scutellum.

(Rincon-Limas et al., 1999)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\LHX2^Scer\UAS.cRa

Hsap\LHX2^UAS.cRa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Rincon-Limas

(Rodriguez-Esteban et al., 1998)

Secondary FlyBase IDs

References (2)

Report Sections

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