FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dr11
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General Information
Symbol
Dmel\Dr11
Species
D. melanogaster
Name
FlyBase ID
FBal0093453
Feature type
allele
Associated gene
Dmel\D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
chemical
(Sanchez Soriano and Russell, 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: G?S. Mutation is in the second helix of the DNA-binding domain.

(Sanchez Soriano and Russell, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:14,176,810..14,176,810 [-]
Nucleotide change:

G14176810A

Amino acid change:

G177S | D-PA; G177S | D-PB; G177S | D-PC; G177S | D-PD

Reported amino acid change:

G?S

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Mutation substitutes S for highly conserved G in the second helix of the DNA-binding HMG domain.

(Sanchez Soriano and Russell, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous viable, lethal in combination with Dunspecified. 30% of hemizygous embryos have segmentation defects that are almost always restricted to the first and fourth abdominal segments. 80% of hemizygous embryos have neuropile defects and 30% have disruptions throughout the whole nerve cord, showing thinning of longitudinal connectives and fusion of commissures.

      (Sanchez Soriano and Russell, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dr11 vvlZm double homozygous embryos have far more pronounced nervous system defects than either single homozygote, and the defects occur in almost every segment. Most of the longitudinal axons cross the midline many times with a robo-like phenotype.

      (Sanchez Soriano and Russell, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      D11
      (Sanchez Soriano et al., 1997)
      Dr11
      Name Synonyms
      Secondary FlyBase IDs
        References (2)