FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wrapperR175
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General Information
Symbol
Dmel\wrapperR175
Species
D. melanogaster
Name
FlyBase ID
FBal0094264
Feature type
allele
Associated gene
Dmel\wrapper
Associated Insertion(s)
Carried in Construct
Also Known As
wrapper175
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Noordermeer et al., 1998)
Progenitor genotype
wrapperP23
(Noordermeer et al., 1998)
Cytology
Description

Imprecise excision of the P{PZ} element resulting in deletion of wrapper sequences encompassing the third Ig domain to approximately 300bp downstream of the poly-A tail.

(Noordermeer et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Vast majority of wrapperR175 homozygous embryos fail to hatch into larvae but some make to third instar stage and of those about half survive to adulthood.

      (Banerjee et al., 2017)

      The initial stages of commissure formation appear normal in homozygous embryos. However, at stage 16, abnormalities are seen in commissural architecture; the two commissures fail to separate completely and several axon bundles straddle and wander in the area between the two commissures.

      (Noordermeer et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      wrapperR175 is rescued by wrapperUAS.cNa/Scer\GAL4wrapper.CH321-61P08

      (Banerjee et al., 2017)
      Comments

      Expression of wrapperScer\UAS.cNa under the control of Scer\GAL4wrapper.CH321-61P08 rescues the near complete embryonic lethality of wrapperR175 homozygous mutants - the rescued embryos display larval hatching and adult eclosion rates that are comparable to wild-type.

      (Banerjee et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      R175
      (Noordermeer et al., 1998)
      wrapper175
      (Banerjee et al., 2017, Slováková and Carmena, 2011)
      wrapperR175
      Name Synonyms
      Secondary FlyBase IDs
        References (3)