FlyBase Allele Report: Dmel\N[lexA.UAS]

General Information

Symbol

Dmel\N^lexA.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0094662

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N.LexA}

Also Known As

N^LexA

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Kidd et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-N.LexA}

Cytology

Description

Full length coding region of N is fused in frame to the Ecol\lexA DNA-binding domain. Expression is governed by UASt regulatory region.

(Kidd et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

presumptive embryonic/larval peripheral nervous system, with Scer\GAL4^da.G32

(Kidd and Lieber, 2002)

Detailed Description

Statement

Reference

Expression of N^{Scer\UAS.T:Ecol\lexA} under the control of Scer\GAL4^da.G32 in a wild-type background results in loss of peripheral nervous system elements.

(Kidd and Lieber, 2002)

Expression of N^{Scer\UAS.T:Ecol\lexA} when driven by Scer\GAL4^da.G32 has no effect on the embryonic nervous system.

(Lieber et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

N^lexA.UAS/Scer\GAL4^da.G32 is a suppressor of presumptive embryonic/larval central nervous system | germline clone phenotype of kuz^e29-4

(Lieber et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

N^lexA.UAS/Scer\GAL4^da.G32 rescues N^264-47

(Kidd and Lieber, 2002)

N^lexA.UAS/Scer\GAL4^unspecified rescues N^unspecified

(Kidd et al., 1998)

Comments

Expression of N^{Scer\UAS.T:Ecol\lexA} under the control of Scer\GAL4^da.G32 rescues the N^264-47 neurogenic phenotype.

(Kidd and Lieber, 2002)

Rescues the neurogenic phenotype of zygotically N^- embryos.

(Kidd et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

N^Lex

(Kidd et al., 1998)

N^LexA

(Kidd and Lieber, 2002, Lieber et al., 2002, Kidd et al., 1998)

N^{Scer\UAS.T:Ecol\lexA}

N^UAS.T:LexA

N^lexA.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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