scutum & macrochaeta
kuze29-4/kuze29-4, Df(3L)ED225/Df(3L)ED225 double mutant embryos display a similar degree of supernumerary Ap neurons, but an enhanced supernumerary EL neuron phenotype, as compared to kuze29-4/kuze29-4 single mutants. These double mutants also display increased proliferation of thoracic neuroblasts at stage 15 (but not stage 12 or 14), thoracic neuroblast daughter cells at stage 14 and 15 (but not stage 12), and abdominal neuroblasts and neuroblast daughter cells at stage 14 and 15 (but not stage 12), as compared with controls.
kuze29-4/+, dap7867/+ double mutant embryos display a significant increase in the number of Ap neurons and EL neurons, and show increased proliferation of neuroblast daughter cells, but not neuroblasts, as compared to controls.
Expression of dapScer\UAS.cUa under the control of Scer\GAL4elav.PU partially suppresses the increased Ap neuron number phenotype, and fully suppresses the increased EL neuron number phenotype, and suppresses the increased daughter cell proliferation of kuze29-4/kuze29-4 mutants.
kuze29-4 ; pros17 double mutant embryos show extensive overproliferation of the entire NB5-6T lineage, with an average of 69 cells. There is an increase in the number of "Ap" neurons generated in the NB5-6T lineage in the double mutant embryos compared to kuze29-4 single mutant embryos.