FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hbsRNAi.UAS.cUa
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General Information
Symbol
Dmel\hbsRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0277770
Feature type
allele
Associated gene
Dmel\hbs
Associated Insertion(s)
Carried in Construct
P{UAS-hbs.RNAi.U}
Key Links
Transgenic product class
RNAi_reagent
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-hbs.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of an RNAi construct targeting hbs.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
hbs
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The eyes of flies expressing hbsVDRC.cUa under the control of Scer\GAL4hs.2sev display dosage-dependent planar cell polarity (PCP) defects manifesting as symmetrical clusters of the R3-R3 type, ommatidial rotation defects, and occasional loss of photoreceptors. Expression of hbsVDRC.cUa at 29[o]C (presumably due to higher Scer\GAL4 activity) results in stronger PCP defects.

      hbs459/+ dominantly enhances the Scer\GAL4hs.2sev>hbsVDRC.cUa-induced planar cell polarity phenotype in the eye.

      Expression of hbsVDRC.cUa in the posterior compartment of the wing under the control of Scer\GAL4en-e16E results in wing notching.

      Loss of notal microchaetae is observed when hbsVDRC.cUa is expressed under the control of Scer\GAL4pnr-MD237.

      (Singh and Mlodzik, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Scer\GAL4hs.2sev, hbsRNAi.UAS.cUa has eye phenotype, non-enhanceable by kuz[+]/kuze29-4

      (Singh and Mlodzik, 2012)

      Scer\GAL4hs.2sev, hbsRNAi.UAS.cUa has ommatidium phenotype, non-enhanceable by kuz[+]/kuze29-4

      (Singh and Mlodzik, 2012)
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4hs.2sev, hbsRNAi.UAS.cUa has eye phenotype, non-suppressible by kuz[+]/kuze29-4

      (Singh and Mlodzik, 2012)

      Scer\GAL4hs.2sev, hbsRNAi.UAS.cUa has ommatidium phenotype, non-suppressible by kuz[+]/kuze29-4

      (Singh and Mlodzik, 2012)
      Enhancer of
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      N55e11/+ strongly enhances the Scer\GAL4hs.2sev>hbsVDRC.cUa-induced eye phenotype. Specifically, N55e11/+, Scer\GAL4hs.2sev>hbsVDRC.cUa eyes display a marked increase in R3-R3 symmetrical clusters compared with Scer\GAL4hs.2sev>hbsVDRC.cUa eyes.

      The number of R4-R4 clusters in eyes expressing NΔECN.sev is markedly reduced by co-expression of hbsVDRC.cUa via Scer\GAL4hs.2sev. Notably, even R3-R3 symmetrical clusters, never seen in NΔECN.sev background, are observed in Scer\GAL4hs.2sev>hbsVDRC.cUa, NΔECN.sev.

      kuze29-4/+ has no detectable effect on the eye-phenotype resulting from the expression of hbsVDRC.cUa under the control of Scer\GAL4hs.2sev.

      Psn143/+ dominantly enhances the frequency of R3-R3 symmetrical clusters induced by Scer\GAL4hs.2sev>hbsVDRC.cUa.

      Psn9/+ dominantly enhances the frequency of R3-R3 symmetrical clusters induced by Scer\GAL4hs.2sev>hbsVDRC.cUa.

      Expression of PsnVDRC.cUa in the eye enhances the Scer\GAL4hs.2sev>hbsVDRC.cUa induced planar cell polarity (PCP) phenotype.

      nctA7/+ enhances the Scer\GAL4hs.2sev>hbsVDRC.cUa-induced planar cell polarity (PCP) phenotype in the eye.

      Co-expression of hbsVDRC.cUa with ApplJF02878 under the control of Scer\GAL4hs.2sev significantly enhances the hbsVDRC.cUa-induce planar cell polarity (PCP) phenotype.

      (Singh and Mlodzik, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hbsRNAi.UAS.cUa
      hbsVDRC.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)