FlyBase Allele Report: Dmel\Nct[A7]

General Information

Symbol

Dmel\Nct^A7

Species

D. melanogaster

Name

FlyBase ID

FBal0129205

Feature type

allele

Associated gene

Dmel\Nct

Associated Insertion(s)

Carried in Construct

Also Known As

Nic^A7

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hu et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q640term.

(Hu et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:24,853,929..24,853,929 [+]

Nucleotide change:

C24853929T

Amino acid change:

Q640term | nct-PA; Q640term | nct-PC; Q640term | nct-PD; Q640term | nct-PE

Reported amino acid change:

Q640term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hu et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | germline clone | neurogenic phenotype | recessive

(Hu et al., 2002)

lethal | larval stage | recessive

(Hu et al., 2002)

Phenotype Manifest In

larva

(Hu et al., 2002)

microchaeta | somatic clone

(Hu et al., 2002)

presumptive embryonic/larval central nervous system | germline clone

(Hu et al., 2002)

sensory mother cell & dorsal mesothoracic disc

(Hu et al., 2002)

wing | somatic clone

(Hu et al., 2002)

wing disc

(Hu et al., 2002)

wing margin | somatic clone

(Hu et al., 2002)

wing vein | somatic clone

(Hu et al., 2002)

Detailed Description

Statement

Reference

Mutant larvae secrete a pupal case but do not form any adult structures and instead collapse into an oily mass within the pupal case. Clusters of sensillum precursors in the wing disc are expanded. Wing discs are reduced in size as compared to wild-type. Embryos derived from homozygous germ-line clones show N-like lethal hyperplasia of the embryonic central nervous system. A small fraction of these can be rescued by paternally-contributed wild type nct to produce normal adult flies. Somatic clones examined in the adult show N-like phenotypes such as wing notching, wing vein thickening and bald patches on thoracic cuticle.

(Hu et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

nct[+]/Nct^A7 is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, hbs^RNAi.UAS.cUa

(Singh and Mlodzik, 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Nct^A7 has sensory mother cell & dorsal mesothoracic disc phenotype, suppressible by N^int.hs

(Hu et al., 2002)

Nct^A7 has wing disc phenotype, suppressible by N^int.hs

(Hu et al., 2002)

Nct^A7 has wing disc phenotype, suppressible | partially by N^ECN.hs

(Hu et al., 2002)

NOT suppressed by

Statement

Reference

Nct^A7 has sensory mother cell & dorsal mesothoracic disc phenotype, non-suppressible by N^ECN.hs

(Hu et al., 2002)

Enhancer of

Statement

Reference

nct[+]/Nct^A7 is an enhancer of eye phenotype of Scer\GAL4^hs.2sev, hbs^RNAi.UAS.cUa

(Singh and Mlodzik, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

nct^A7/+ enhances the Scer\GAL4^hs.2sev>hbs^VDRC.cUa-induced planar cell polarity (PCP) phenotype in the eye.

(Singh and Mlodzik, 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

41781

w^*; Nct^A7/TM6C, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nct^A7

Nic^A7

(Koelzer and Klein, 2006, Hu et al., 2002)

nct^A7

(Restrepo et al., 2022, Singh and Mlodzik, 2012, Guo et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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