FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\C3GΔ.UAS.Tag:MYC,Tag:M(c-SRC)
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General Information
Symbol
Dmel\C3GΔ.UAS.Tag:MYC,Tag:M(c-SRC)
Species
D. melanogaster
Name
FlyBase ID
FBal0094888
Feature type
allele
Associated gene
Dmel\C3G
Associated Insertion(s)
Carried in Construct
P{UAS-C3G.Δ.T:Myc.T:Myr3}
Key Links
Transgenic product class
inframe_deletion
(Ishimaru et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Ishimaru et al., 1999)
Mutagen
in vitro construct
(Ishimaru et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-C3G.Δ.T:Myc.T:Myr3}
Cytology
Description

A truncated form of C3G (lacking amino acids 1145 to 1383, the CDC25-homologous domain) tagged with 6 copies of the Tag:MYC tag is expressed under the control of UASt regulatory sequences. The C3G sequences are also tagged at the 5' end with Tag:M(c-SRC), to produce a membrane-targetted protein.

(Ishimaru et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
C3G
Tagged with
Tag:M(c-SRC)
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      C3GΔ.Scer\UAS.T:Hsap\MYC,T:Ggal\Myr3 driven by Scer\GAL4Mef2.PR results in viable flies with no obvious changes in actin organisation.

      (Shirinian et al., 2010)

      Flies expressing at least two copies of C3GΔ.Scer\UAS.T:Hsap\MYC,T:Ggal\Myr3 under the control of Scer\GAL4GMR.PF have a severe eye phenotype. The eye is much reduced in size and is often tear-shaped (indicating that the development of the ventral part of the eye is more strongly affected than the dorsal part). Lens facets are formed, but bristles are completely absent from the eye surface. There is a reasonably well formed pigment cell lattice surrounding the ommatidia, but the number of photoreceptor cells per ommatidium is often reduced by 1 or 2 cells. The orientation of the ommatidia is random. The third vein fails to reach the wing margin in flies expressing C3GΔ.Scer\UAS.T:Hsap\MYC,T:Ggal\Myr3 under the control of Scer\GAL4dpp.blk1 and the anterior crossvein is missing.

      (Ishimaru et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      C3GΔ.Scer\UAS.T:Hsap\MYC,T:Ggal\Myr-SRC
      C3GΔ.Scer\UAS.T:Hsap\MYC,T:Ggal\Myr3
      C3GΔ.UAS.T:Myc,T:Myr3
      C3GΔ.UAS.Tag:MYC,Tag:M(c-SRC)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)