FB2026_03 , released September 17, 2026
Allele: Dmel\rdgBsu100
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General Information
Symbol
Dmel\rdgBsu100
Species
D. melanogaster
Name
FlyBase ID
FBal0095235
Feature type
allele
Associated gene
Dmel\rdgB
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Paetkau et al., 1999)
Progenitor genotype
rdgB9
(Paetkau et al., 1999)
Cytology
Description

H542E and D543H lie in the first putative lumenal loop. Although rdgBsu100 contains the Q147term mutation found in the progenitor rdgB9 allele, full-length protein is produced, probably by translation through the nonsense mutation, rather than by alternative splicing.

(Paetkau et al., 1999)

Amino acid replacement: H542E.

(Paetkau et al., 1999)

Amino acid replacement: D543H.

(Paetkau et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:13,769,167..13,769,167 [+]
Nucleotide change:

C13769167T

Amino acid change:

Q147term | rdgB-PA; Q147term | rdgB-PB; Q147term | rdgB-PC; Q147term | rdgB-PD; Q147term | rdgB-PE; Q147term | rdgB-PF; Q147term | rdgB-PG; Q147term | rdgB-PH; Q147term | rdgB-PI; Q147term | rdgB-PJ; Q147term | rdgB-PK

Reported amino acid change:

Q147term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Although mutation would be expected to create truncated protein, full-length protein is produced. Likely a read-through stop codon.

(Paetkau et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      10 day old rdgBsu100 flies raised in a 12 hour light:dark cycle that lack a deep pseudopupil have some disorganised ommatidia and small and/or missing R1-R6 rhabdomeres. R1-R6 photoreceptors are abnormally shaped. Massive degeneration in the retina is not seen. The electroretinogram light response amplitude is reduced compared to wild-type, but the off transient is present.

      (Paetkau et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a suppressor of the rdgB9 retinal degeneration phenotype.

      (Paetkau et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      rdgBsu100
      Name Synonyms
      Secondary FlyBase IDs
        References (1)