FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\e4.6.lacZ
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General Information
Symbol
Dmel\e4.6.lacZ
Species
D. melanogaster
Name
FlyBase ID
FBal0095429
Feature type
allele
Associated gene
Dmel\e
Associated Insertion(s)
Carried in Construct
P{e-lacZ.4.6}
Also Known As
ebony-lacZ
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hovemann et al., 1998)
Progenitor genotype
Carried in construct
P{e-lacZ.4.6}
Cytology
Description

An e genomic fragment extending from 4.6kb upstream of the transcription start site to sequences encoding amino acid 396 in exon III is fused to lacZ.

(Hovemann et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
e
Encoded product / tool
e
Tagged with
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      larval ventral nerve cord | restricted
      (Hovemann et al., 1998)
      larval brain | restricted
      (Hovemann et al., 1998)
      adult stage
      adult ventral nerve cord
      (Hovemann et al., 1998)
      medulla
      (Hovemann et al., 1998)
      lamina
      (Hovemann et al., 1998)
      adult brain
      (Hovemann et al., 1998)
      medulla | distal | restricted
      (Richardt et al., 2002)
      lobula | restricted
      (Richardt et al., 2002)
      lobula plate | restricted
      (Richardt et al., 2002)
      adult optic lobe | restricted
      (Richardt et al., 2002)
      lamina | restricted
      (Richardt et al., 2002)
      Additional Information
      Statement
      Reference

      An eFBtr0091350:pb-XREco/lacZ reporter construct was used to investigate expression in third instar larvae and adults. In adults, strong expression is observed in the lamina with weaker expression in the medulla. Weak staining is also observed in the central brain and thoracic ganglion. In third instar larvae, expression is observed in single cells distributed in two rows along the ventral ganglion and in restricted areas of the brain.

      (Hovemann et al., 1998)
       
      Marker for
      Reflects expression of
      e
      (Richardt et al., 2002, Hovemann et al., 1998)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      e4.6.T:Ecol\lacZ
      e4.6.T:lacZ
      e4.6.lacZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)