FB2026_02 , released June 18, 2026
Allele: Dmel\ari-15777
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General Information
Symbol
Dmel\ari-15777
Species
D. melanogaster
Name
FlyBase ID
FBal0095522
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ari-14
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?91term.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    G18135288T

    Amino acid change:

    E91term | ari-1-PA; E91term | ari-1-PB; E91term | ari-1-PC; E91term | ari-1-PD; E91term | ari-1-PE; E91term | ari-1-PF

    Reported amino acid change:

    ?91term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    ari-15777 repressively leads to a decrease in the frequency of spontaneous miniature events in the larval neuromuscular junction.

    Adult male survivors are seen at a low frequency (less than 10%). New or aberrant versions of normal axonal bundles are found in the brain and thoracic ganglia of gynandromorphs. Occasionally a major bundle is missing, such as the descending path that carries one of the two cervical giant fibers. All abnormal bundles consist of coherent groups of axons that project along unusual paths rather than disorganised or aborted individual axons. The negative sustained component of the electroretinogram of mutant escapers is reduced to 1/3 of controls. The amplitude of the on and off transients is reduced by approximately 60%. Females carrying homozygous germline clones can produce offspring, indicating that the ari-15777 mutation does not prevent oogenesis.

    External Data
    Interactions
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    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (3)