FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nSybunspecified
Open Close
General Information
Symbol
Dmel\nSybunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0096744
Feature type
allele
Associated gene
Dmel\nSyb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        synaptic vesicle & eye photoreceptor cell | somatic clone

        (Hiesinger et al., 2005)
        Detailed Description
        Statement
        Reference

        When eye photoreceptor cells are selectively made homozygous for n-sybunspecified (using Scer\FLP1ey.3.5.hs; Scer\FRT n-sybunspecified/Scer\FRT 'cell-lethal'), their terminals in the lamina have a higher density of vesicles than to wild-type. In addition the number of capitate projections (dynamically active invaginations of the surrounding epithelial glia associated with vesicle endocytosis) is reduced. The numbers of active zones and mitochondria per terminal are unaltered in mutant photoreceptor cells.

        (Hiesinger et al., 2005)

        Mutant embryos have aerated tracheae at 21-24 hours after egg laying but do not move spontaneously within the vitelline membrane. If the membrane is torn with a sharp needle, the embryos show wiggly movements; segmental muscles at various positions contract sporadically for several minutes until the embryos eventually become placid.

        (Yoshihara et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        n-Sybunspecified
        n-sybunspecified
        nSybunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)