FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Xpdhs.PR
Open Close
General Information
Symbol
Dmel\Xpdhs.PR
Species
D. melanogaster
Name
heat shock construct of Reynaud
FlyBase ID
FBal0097083
Feature type
allele
Associated gene
Dmel\Xpd
Associated Insertion(s)
Carried in Construct
P{hs-Xpd.R}
Key Links
Transgenic product class
cDNA
(Reynaud et al., 1999)
wild_type
(Reynaud et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Reynaud et al., 1999)
wild_type
(Reynaud et al., 1999)
Mutagen
in vitro construct
(Reynaud et al., 1999)
Progenitor genotype
Carried in construct
P{hs-Xpd.R}
Cytology
Description

An Hsp70 promoter drives expression of an Xpd cDNA.

(Reynaud et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Xpd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In 2-3 hour old mutant embryos, heat treatment causes half of them to show a lethal phenotype 90 minutes into the recovery period. large areas of DNA aggregation, irregular mitotic figures and degenerating cells are seen. Cells undergo metaphase arrest - many additional metaphase figures are seen. Other cells appear to arrest at G2/M and prophase. Daily induction of Xpdhs.PR leads to a viability of about 14%. This is partly restored to 40% in Df/Xpd+ Xpdhs.PR animals. When Xpdhs.PR overexpression is induced at cycle 13, cells appear to skip mitotic phase 13 and continue with cycle 14.

      (Chen et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Xpdhs.PR
      Name Synonyms
      heat shock construct of Reynaud
      (Reynaud et al., 1999)
      Secondary FlyBase IDs
        References (2)