FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Src42A7-4
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General Information
Symbol
Dmel\Src42A7-4
Species
D. melanogaster
Name
FlyBase ID
FBal0097110
Feature type
allele
Associated gene
Dmel\Src42A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lu and Li, 1999)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      10% of eggs laid by heterozygous females are completely dorsalised. Src42A7-4/Df(2R)nap9 animals show defects in head involution, tail morphology and tracheal necrosis.

      (Lu and Li, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Src42A7-4 is an enhancer of visible phenotype of Ras85DV12.sev

      (Lu and Li, 1999)

      Src42A7-4 is an enhancer of visible phenotype of Raf::tor13D.hs.sev

      (Lu and Li, 1999)
      Suppressor of
      Statement
      Reference

      Src42A7-4 is a suppressor of lethal phenotype of Raf1

      (Lu and Li, 1999)
      Other
      Statement
      Reference

      Raf1, Src42A7-4 has viable phenotype

      (Lu and Li, 1999)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Src42A7-4 is an enhancer of eye phenotype of Ras85DV12.sev

      (Lu and Li, 1999)

      Src42A7-4 is an enhancer of eye phenotype of Raf::tor13D.hs.sev

      (Lu and Li, 1999)
      Suppressor of
      Statement
      Reference

      Src42A7-4 is a suppressor of embryonic abdominal segment 8 phenotype of Ras85DΔC40B

      (Lu and Li, 1999)

      Src42A7-4 is a suppressor of filzkorper phenotype of Ras85DΔC40B

      (Lu and Li, 1999)

      Src42A7-4 is a suppressor of wing vein phenotype of SosAM14

      (Lu and Li, 1999)

      Src42A7-4 is a suppressor of wing vein phenotype of Sosx122

      (Lu and Li, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppresses the lethality of phl1. Enhances the rough eye phenotype of Ras85DV12.sev and phl::tor13D.hs.sev. Sosx122/SosAM14 flies show loss of wing veins. This phenotype is partially suppressed by one copy of Src42A7-4. Partly suppresses the maternal effect phenotype of Ras85DΔC40B; embryos derived from homozygous Ras85DΔC40B female germline clones develop abdominal segment A8 in 20.3% of cases and filzkorper in 0.4% of cases. A higher proportion of these embryos develop abdominal segment A8 (52.9%) or filzkorper (12.4%) if the females are also carrying Src42A7-4.

      (Lu and Li, 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Src42ASu(Raf)1-1

      (Lu and Li, 1999)
      Rescued by

      Src42A7-4 is rescued by Src42AUbi-p63E.PL

      (Lu and Li, 1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Src42A7-4
      l(2)7-4
      (Lu and Li, 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)