FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gbb3
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General Information
Symbol
Dmel\gbb3
Species
D. melanogaster
Name
FlyBase ID
FBal0098238
Feature type
allele
Associated gene
Dmel\gbb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Bangi and Wharton, 2006, Ray and Wharton, 2001, Wharton et al., 1999)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G408A. Amino acid replacement: M1I. Coordinates as in FBrf0054935.

    (Wharton et al., 1999)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:23,851,757..23,851,757 [+]
    Nucleotide change:

    G23851757A

    Reported nucleotide change:

    G408A

    Amino acid change:

    M1I | gbb-PA; M1I | gbb-PB

    Reported amino acid change:

    M1I

    (Wharton et al., 1999)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The intracellular lipid droplets in gbb3 mutant fat body cells are more variable in size than that seen in wild-type fat bodies.

        Late third instar gbb1/gbb3 mutant wing imaginal discs are 50% smaller in overall area compared to the area of wild-type wing discs of the same developmental stage.

        gbb1/gbb3 mutant larvae do not show a significant difference in overall protein levels compared to wild-type third instar larvae when normalised for body mass.

        gbb1/gbb3 mutant third instar larvae have lower levels of glucose and trehalose levels than wild-type controls.

        gbb1/gbb3 mutant third instar larvae show increased uptake and transport of ingested fluorescently labeled fatty acids from the midgut lumen to the fat body compared to wild-type controls.

        (Ballard et al., 2010)

        gbb3/gbb4 adults lack the posterior crossvein, vein L5 is truncated to the base and L4 is truncated distally. The overall size of the wing is reduced compared to wild type.

        (Ray and Wharton, 2001)

        Less than 10% of mutants dies as embryos. Mutant larvae are lethargic and flaccid. Imaginal discs are dramatically reduced. Fat body morphology is abnormal, giving rise to transparent phenotype. Cuticle exhibits defects in the telson region. In severe cases posterior spiracles do not protrude from the larval bosy and the stigmatophores are partially fused and more dorsally situated.

        (Wharton et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Hemizygotes over Df(2R)b23 show a more severe phenotype than homozygotes. The gbb alleles fall into a phenotypic series. Starting with the most severe alleles: gbb1 = gbb2 > gbb3 > gbb4.

        (Wharton et al., 1999)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        An-4
        (Wharton et al., 1999)
        gbb3
        (Anderson and Wharton, 2017, Akiyama et al., 2012, Ballard et al., 2010, Bangi and Wharton, 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)