FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Bro::HsapMYH11UAS.cLa
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General Information
Symbol
Dmel\Bro::Hsap\MYH11UAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Li
FlyBase ID
FBal0098939
Feature type
allele
Associated gene
Bro::Hsap\MYH11
Associated Insertion(s)
Carried in Construct
P{UAS-Bro::Hsap\MYH11.L}
Key Links
Transgenic product class
dominant_negative_variant
(Li and Gergen, 1999)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Li and Gergen, 1999)
Mutagen
in vitro construct
(Li and Gergen, 1999)
Progenitor genotype
Carried in construct
P{UAS-Bro::Hsap\MYH11.L}
Cytology
Description

The first 159 amino acids of Bro fused to the coiled-coil domain of Hsap\MYH11 (amino acids 1527 to 1972) are expressed under the control of UAS regulatory sequences. This functions as a dominant negative form of Bro.

(Li and Gergen, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Bro::Hsap\MYH11
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Bro::Hsap\MYH11Scer\UAS.cLa under the control of Scer\GAL4lz-gal4 results in significant increases in both the number and size of third instar larval circulating crystal cells, as compared to controls.

      (Miller et al., 2017)

      Flies expressing Bro::Hsap\MYH11Scer\UAS.cLa under the control of Scer\GAL4hs.2sev have mild patterning defects in the eye.

      (Li and Gergen, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Enhances the eye phenotype of lz114 males raised at 25oC when expressed under the control of Scer\GAL4hs.2sev. A severe eye phenotype is produced when runScer\UAS.cLa and Bro::Hsap\MYH11Scer\UAS.cLa are coexpressed under the control of Scer\GAL4hs.2sev.

      (Li and Gergen, 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Bro::Hsap\MYH11Scer\UAS.cLa
      Bro::Hsap\MYH11UAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Li
      (Li and Gergen, 1999)
      Secondary FlyBase IDs
        References (2)